FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138801995> ?p ?o ?g. }

• W2138801995 endingPage "864" @default.
• W2138801995 startingPage "857" @default.
• W2138801995 abstract "Objective. There are a significant number of patients with rheumatoid arthritis (RA) of North Indian or Pakistani origin (Asian) now living in the UK. RA has been poorly studied in this racial group. The aim of this study was to compare RA in this Asian group with RA in the indigenous northern European (European) population. It was hypothesized that these two racial groups would have different disease expressions and immunogenetics that could be relevant to pathogenesis, prognosis and therapy. Methods. One hundred and seven Asian RA patients, who fulfilled the 1987 American College of Rheumatology criteria, were stringently matched for age, sex and disease duration with 107 European RA patients, and were fully assessed. Results. The Asian RA patients had significantly fewer bony erosions [median Larsen score 58.5 (interquartile range 45.5–77.8) vs 68 (52–93) for European patients; P = 0.0066, Mann–Whitney U‐test] and rarely had nodules (5.7 vs 20%, P = 0.0019, Fisher's exact test). The two groups had the same prevalence of rheumatoid factor positivity, number of swollen joints and level of inflammation (C‐reactive protein). The Asian RA patients had a reduced prevalence of the conserved third allelic hypervariable region (3AHVR) (45 vs 82%, P < 0.0001, Fisher's exact test), particularly DRB1*0401 (4.5 vs 55%). However, the prevalence of the conserved 3AHVR was significantly increased in the Asian RA patients compared with Asian controls. By contrast, the Asian patients had more tender joints [13.5 (7–22) vs 5.5 (2–11.8); P < 0.0001 Mann–Whitney U‐test]. The Health Assessment Questionnaire score was also significantly worse in the Asians compared with the Europeans [median 2.0 (1.13–2.63) vs 1.25 (0.5–2.13), P = 0.0001). Conclusions. The Asian patients had similar levels of inflammation and less damage but more pain and disability than the matched European RA patients. Of the known prognostic factors for erosions (rheumatoid factor, conserved 3AHVR, swollen joints and C‐reactive protein), only the conserved 3AHVR was reduced in the Asian RA patients, and this was consistent with their less erosive disease. These data also indicate the importance of pain as well as erosive damage in determining disability in Asian patients and stress the importance of adequate pain relief, in addition to disease suppression, when treating Asian RA patients." @default.
• W2138801995 created "2016-06-24" @default.
• W2138801995 creator A5000991227 @default.
• W2138801995 creator A5008642034 @default.
• W2138801995 creator A5008905801 @default.
• W2138801995 creator A5026797171 @default.
• W2138801995 creator A5029470859 @default.
• W2138801995 creator A5086429836 @default.
• W2138801995 date "2000-08-01" @default.
• W2138801995 modified "2023-09-25" @default.
• W2138801995 title "Racial origin and its effect on disease expression and HLA‐DRB1 types in patients with rheumatoid arthritis: a matched cross‐sectional study" @default.
• W2138801995 cites W1966814509 @default.
• W2138801995 cites W1985004174 @default.
• W2138801995 cites W1990226212 @default.
• W2138801995 cites W2000332027 @default.
• W2138801995 cites W2009689493 @default.
• W2138801995 cites W2015865604 @default.
• W2138801995 cites W2055950121 @default.
• W2138801995 cites W2069713723 @default.
• W2138801995 cites W2088180658 @default.
• W2138801995 cites W2088306441 @default.
• W2138801995 cites W2091078676 @default.
• W2138801995 cites W2091943129 @default.
• W2138801995 cites W2095095268 @default.
• W2138801995 cites W2103870440 @default.
• W2138801995 cites W2137452498 @default.
• W2138801995 cites W2150163049 @default.
• W2138801995 cites W2152348310 @default.
• W2138801995 cites W2160377333 @default.
• W2138801995 cites W2164818142 @default.
• W2138801995 cites W2165843763 @default.
• W2138801995 cites W2206746226 @default.
• W2138801995 cites W48375751 @default.
• W2138801995 doi "https://doi.org/10.1093/rheumatology/39.8.857" @default.
• W2138801995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10952739" @default.
• W2138801995 hasPublicationYear "2000" @default.
• W2138801995 type Work @default.
• W2138801995 sameAs 2138801995 @default.
• W2138801995 citedByCount "40" @default.
• W2138801995 countsByYear W21388019952013 @default.
• W2138801995 countsByYear W21388019952014 @default.
• W2138801995 countsByYear W21388019952016 @default.
• W2138801995 countsByYear W21388019952017 @default.
• W2138801995 countsByYear W21388019952018 @default.
• W2138801995 countsByYear W21388019952019 @default.
• W2138801995 countsByYear W21388019952020 @default.
• W2138801995 countsByYear W21388019952021 @default.
• W2138801995 countsByYear W21388019952022 @default.
• W2138801995 crossrefType "journal-article" @default.
• W2138801995 hasAuthorship W2138801995A5000991227 @default.
• W2138801995 hasAuthorship W2138801995A5008642034 @default.
• W2138801995 hasAuthorship W2138801995A5008905801 @default.
• W2138801995 hasAuthorship W2138801995A5026797171 @default.
• W2138801995 hasAuthorship W2138801995A5029470859 @default.
• W2138801995 hasAuthorship W2138801995A5086429836 @default.
• W2138801995 hasBestOaLocation W21388019951 @default.
• W2138801995 hasConcept C119060515 @default.
• W2138801995 hasConcept C126322002 @default.
• W2138801995 hasConcept C12868164 @default.
• W2138801995 hasConcept C1547928 @default.
• W2138801995 hasConcept C159654299 @default.
• W2138801995 hasConcept C191093355 @default.
• W2138801995 hasConcept C198451711 @default.
• W2138801995 hasConcept C203014093 @default.
• W2138801995 hasConcept C2776232647 @default.
• W2138801995 hasConcept C2777575956 @default.
• W2138801995 hasConcept C2777840918 @default.
• W2138801995 hasConcept C2780942790 @default.
• W2138801995 hasConcept C2908647359 @default.
• W2138801995 hasConcept C71924100 @default.
• W2138801995 hasConcept C90924648 @default.
• W2138801995 hasConcept C99454951 @default.
• W2138801995 hasConceptScore W2138801995C119060515 @default.
• W2138801995 hasConceptScore W2138801995C126322002 @default.
• W2138801995 hasConceptScore W2138801995C12868164 @default.
• W2138801995 hasConceptScore W2138801995C1547928 @default.
• W2138801995 hasConceptScore W2138801995C159654299 @default.
• W2138801995 hasConceptScore W2138801995C191093355 @default.
• W2138801995 hasConceptScore W2138801995C198451711 @default.
• W2138801995 hasConceptScore W2138801995C203014093 @default.
• W2138801995 hasConceptScore W2138801995C2776232647 @default.
• W2138801995 hasConceptScore W2138801995C2777575956 @default.
• W2138801995 hasConceptScore W2138801995C2777840918 @default.
• W2138801995 hasConceptScore W2138801995C2780942790 @default.
• W2138801995 hasConceptScore W2138801995C2908647359 @default.
• W2138801995 hasConceptScore W2138801995C71924100 @default.
• W2138801995 hasConceptScore W2138801995C90924648 @default.
• W2138801995 hasConceptScore W2138801995C99454951 @default.
• W2138801995 hasIssue "8" @default.
• W2138801995 hasLocation W21388019951 @default.
• W2138801995 hasLocation W21388019952 @default.
• W2138801995 hasOpenAccess W2138801995 @default.
• W2138801995 hasPrimaryLocation W21388019951 @default.
• W2138801995 hasRelatedWork W1556726349 @default.
• W2138801995 hasRelatedWork W1978435955 @default.
• W2138801995 hasRelatedWork W1979208269 @default.
• W2138801995 hasRelatedWork W1998217896 @default.
• W2138801995 hasRelatedWork W2023721760 @default.

• next