Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138810805> ?p ?o ?g. }
- W2138810805 endingPage "561" @default.
- W2138810805 startingPage "547" @default.
- W2138810805 abstract "The mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena. We previously reported that addition of low-dose recombinant human TNF (rhTNF) at the fracture site augmented fracture repair in a murine tibial fracture model. Here, we show that local rhTNF treatment is only effective when administered within 24 h of injury, when neutrophils are the major inflammatory cell infiltrate. Systemic administration of anti-TNF impaired fracture healing. Addition of rhTNF enhanced neutrophil recruitment and promoted recruitment of monocytes through CCL2 production. Conversely, depletion of neutrophils or inhibition of the chemokine receptor CCR2 resulted in significantly impaired fracture healing. Fragility, or osteoporotic, fractures represent a major medical problem as they are associated with permanent disability and premature death. Using a murine model of fragility fractures, we found that local rhTNF treatment improved fracture healing during the early phase of repair. If translated clinically, this promotion of fracture healing would reduce the morbidity and mortality associated with delayed patient mobilization." @default.
- W2138810805 created "2016-06-24" @default.
- W2138810805 creator A5002329871 @default.
- W2138810805 creator A5005133925 @default.
- W2138810805 creator A5029898055 @default.
- W2138810805 creator A5036313179 @default.
- W2138810805 creator A5043932592 @default.
- W2138810805 creator A5045563269 @default.
- W2138810805 creator A5045887566 @default.
- W2138810805 creator A5054330230 @default.
- W2138810805 creator A5056454325 @default.
- W2138810805 creator A5056946750 @default.
- W2138810805 creator A5057580992 @default.
- W2138810805 creator A5058026351 @default.
- W2138810805 creator A5073748817 @default.
- W2138810805 creator A5079500211 @default.
- W2138810805 date "2015-03-14" @default.
- W2138810805 modified "2023-10-10" @default.
- W2138810805 title "Low‐dose <scp>TNF</scp> augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response" @default.
- W2138810805 cites W1559448597 @default.
- W2138810805 cites W1802397357 @default.
- W2138810805 cites W1894961002 @default.
- W2138810805 cites W1899364733 @default.
- W2138810805 cites W1942966726 @default.
- W2138810805 cites W1967549460 @default.
- W2138810805 cites W1970308804 @default.
- W2138810805 cites W1973035338 @default.
- W2138810805 cites W1974361804 @default.
- W2138810805 cites W1981987409 @default.
- W2138810805 cites W1982404814 @default.
- W2138810805 cites W1992232557 @default.
- W2138810805 cites W1999581053 @default.
- W2138810805 cites W2004600858 @default.
- W2138810805 cites W2005528887 @default.
- W2138810805 cites W2007569370 @default.
- W2138810805 cites W2009699689 @default.
- W2138810805 cites W2010472544 @default.
- W2138810805 cites W2010517016 @default.
- W2138810805 cites W2014679360 @default.
- W2138810805 cites W2015739140 @default.
- W2138810805 cites W2017057091 @default.
- W2138810805 cites W2019451761 @default.
- W2138810805 cites W2020545615 @default.
- W2138810805 cites W2024470090 @default.
- W2138810805 cites W2024778918 @default.
- W2138810805 cites W2025061038 @default.
- W2138810805 cites W2028228531 @default.
- W2138810805 cites W2028627202 @default.
- W2138810805 cites W2029631026 @default.
- W2138810805 cites W2030481961 @default.
- W2138810805 cites W2031330565 @default.
- W2138810805 cites W2032491472 @default.
- W2138810805 cites W2035424618 @default.
- W2138810805 cites W2036852690 @default.
- W2138810805 cites W2037716466 @default.
- W2138810805 cites W2050805027 @default.
- W2138810805 cites W2052192250 @default.
- W2138810805 cites W2052690873 @default.
- W2138810805 cites W2053296436 @default.
- W2138810805 cites W2056823987 @default.
- W2138810805 cites W2057837736 @default.
- W2138810805 cites W2060576112 @default.
- W2138810805 cites W2060609132 @default.
- W2138810805 cites W2060816393 @default.
- W2138810805 cites W2061790220 @default.
- W2138810805 cites W2063693593 @default.
- W2138810805 cites W2069375519 @default.
- W2138810805 cites W2070806136 @default.
- W2138810805 cites W2072164551 @default.
- W2138810805 cites W2072478343 @default.
- W2138810805 cites W2073184155 @default.
- W2138810805 cites W2074171762 @default.
- W2138810805 cites W2074226229 @default.
- W2138810805 cites W2078815174 @default.
- W2138810805 cites W2081119605 @default.
- W2138810805 cites W2085099489 @default.
- W2138810805 cites W2085268252 @default.
- W2138810805 cites W2086697911 @default.
- W2138810805 cites W2086956040 @default.
- W2138810805 cites W2091446773 @default.
- W2138810805 cites W2093785176 @default.
- W2138810805 cites W2098190902 @default.
- W2138810805 cites W2098635583 @default.
- W2138810805 cites W2100185747 @default.
- W2138810805 cites W2101367251 @default.
- W2138810805 cites W2101444839 @default.
- W2138810805 cites W2104357139 @default.
- W2138810805 cites W2111194166 @default.
- W2138810805 cites W2112174625 @default.
- W2138810805 cites W2113441397 @default.
- W2138810805 cites W2117985944 @default.
- W2138810805 cites W2119618747 @default.
- W2138810805 cites W2120061572 @default.
- W2138810805 cites W2128299225 @default.
- W2138810805 cites W2135735584 @default.
- W2138810805 cites W2142361972 @default.
- W2138810805 cites W2146468369 @default.
- W2138810805 cites W2148685973 @default.