FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138812066> ?p ?o ?g. }

• W2138812066 endingPage "239" @default.
• W2138812066 startingPage "230" @default.
• W2138812066 abstract "Summary Aims Advanced glycation end products (AGE), which form from the non‐enzymatic reaction of proteins and sugars, have been implicated in the pathogenesis of diabetic nephropathy. Recently, a compound [N‐phenacylthiazolium bromide (PTB)] has been described which cleaves α,β‐dicarbonyl compounds. In the present study we used diabetic C57BL/6 mice to determine if PTB altered renal AGE levels and reduced diabetic glomerulosclerosis. Methods Mice with stable hyperglycaemia induced by streptozotocin were given daily subcutaneous injections of either PTB (10 μg/g) or saline for 12 weeks. Renal‐collagen bound AGE and urinary AGE‐peptides were measured by ELISA using an anti‐AGE‐RNase antibody. Renal collagen‐released N ε (carboxymethyl)lysine (CML) and pentosidine were determined by high pressure liquid chromatography (HPLC). Glomerular lesions (volume and mesangial/total surface area) were evaluated by computer‐assisted image analysis. We determined urinary protein/creatinine ratio as a functional parameter. AGE localization was examined by immunohistochemistry using the anti‐AGE‐RNase antibody. Results Renal collagen‐bound AGE were decreased and urinary AGE excretion was increased in PTB‐treated diabetic mice. However, collagen‐released CML and pentosidine were similar in both groups. Glomerular histology and morphometric analysis revealed also no differences between PTB‐and saline‐treated diabetic mice. The urinary protein/creatinine ratio was unaffected by PTB‐treatment. AGE staining by anti‐AGE‐RNase antibody was present in Bowman's capsules, glomerular basement membranes and cortical tubules. It was decreased in all structures in PTB‐treated diabetic mice. Conclusion In summary, PTB decreased renal AGE accumulation but did not ameliorate glomerular lesions or proteinuria. Thus, cleavage of AGE by PTB is not sufficient to prevent development of diabetic nephropathy in C57BL/6 mice." @default.
• W2138812066 created "2016-06-24" @default.
• W2138812066 creator A5001674855 @default.
• W2138812066 creator A5002726308 @default.
• W2138812066 creator A5006898735 @default.
• W2138812066 creator A5017298005 @default.
• W2138812066 creator A5039546853 @default.
• W2138812066 creator A5042797957 @default.
• W2138812066 creator A5057775242 @default.
• W2138812066 creator A5061116088 @default.
• W2138812066 creator A5086670020 @default.
• W2138812066 date "2001-08-01" @default.
• W2138812066 modified "2023-10-18" @default.
• W2138812066 title "N-phenacylthiazolium bromide decreases renal and increases urinary advanced glycation end products excretion without ameliorating diabetic nephropathy in C57BL/6 mice" @default.
• W2138812066 cites W1556333628 @default.
• W2138812066 cites W1561751955 @default.
• W2138812066 cites W1976577674 @default.
• W2138812066 cites W1984870498 @default.
• W2138812066 cites W1995428435 @default.
• W2138812066 cites W1998498936 @default.
• W2138812066 cites W2016739088 @default.
• W2138812066 cites W2017214714 @default.
• W2138812066 cites W2019704017 @default.
• W2138812066 cites W2025016154 @default.
• W2138812066 cites W2025748287 @default.
• W2138812066 cites W2031283045 @default.
• W2138812066 cites W2033066650 @default.
• W2138812066 cites W2035493509 @default.
• W2138812066 cites W2041391173 @default.
• W2138812066 cites W2052681712 @default.
• W2138812066 cites W2065012620 @default.
• W2138812066 cites W2067679923 @default.
• W2138812066 cites W2072692635 @default.
• W2138812066 cites W2072990621 @default.
• W2138812066 cites W2085341182 @default.
• W2138812066 cites W2107516773 @default.
• W2138812066 cites W2143025008 @default.
• W2138812066 cites W2164553737 @default.
• W2138812066 cites W2335364913 @default.
• W2138812066 cites W2769264260 @default.
• W2138812066 cites W3024383408 @default.
• W2138812066 cites W4233774258 @default.
• W2138812066 cites W4238225767 @default.
• W2138812066 doi "https://doi.org/10.1046/j.1463-1326.2001.00096.x" @default.
• W2138812066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11520302" @default.
• W2138812066 hasPublicationYear "2001" @default.
• W2138812066 type Work @default.
• W2138812066 sameAs 2138812066 @default.
• W2138812066 citedByCount "18" @default.
• W2138812066 countsByYear W21388120662012 @default.
• W2138812066 countsByYear W21388120662016 @default.
• W2138812066 countsByYear W21388120662022 @default.
• W2138812066 crossrefType "journal-article" @default.
• W2138812066 hasAuthorship W2138812066A5001674855 @default.
• W2138812066 hasAuthorship W2138812066A5002726308 @default.
• W2138812066 hasAuthorship W2138812066A5006898735 @default.
• W2138812066 hasAuthorship W2138812066A5017298005 @default.
• W2138812066 hasAuthorship W2138812066A5039546853 @default.
• W2138812066 hasAuthorship W2138812066A5042797957 @default.
• W2138812066 hasAuthorship W2138812066A5057775242 @default.
• W2138812066 hasAuthorship W2138812066A5061116088 @default.
• W2138812066 hasAuthorship W2138812066A5086670020 @default.
• W2138812066 hasConcept C126322002 @default.
• W2138812066 hasConcept C134018914 @default.
• W2138812066 hasConcept C147990577 @default.
• W2138812066 hasConcept C185592680 @default.
• W2138812066 hasConcept C2776115139 @default.
• W2138812066 hasConcept C2776997535 @default.
• W2138812066 hasConcept C2779280383 @default.
• W2138812066 hasConcept C2779561371 @default.
• W2138812066 hasConcept C2779922275 @default.
• W2138812066 hasConcept C2780091579 @default.
• W2138812066 hasConcept C2780306776 @default.
• W2138812066 hasConcept C2781184683 @default.
• W2138812066 hasConcept C555293320 @default.
• W2138812066 hasConcept C71924100 @default.
• W2138812066 hasConcept C77411442 @default.
• W2138812066 hasConceptScore W2138812066C126322002 @default.
• W2138812066 hasConceptScore W2138812066C134018914 @default.
• W2138812066 hasConceptScore W2138812066C147990577 @default.
• W2138812066 hasConceptScore W2138812066C185592680 @default.
• W2138812066 hasConceptScore W2138812066C2776115139 @default.
• W2138812066 hasConceptScore W2138812066C2776997535 @default.
• W2138812066 hasConceptScore W2138812066C2779280383 @default.
• W2138812066 hasConceptScore W2138812066C2779561371 @default.
• W2138812066 hasConceptScore W2138812066C2779922275 @default.
• W2138812066 hasConceptScore W2138812066C2780091579 @default.
• W2138812066 hasConceptScore W2138812066C2780306776 @default.
• W2138812066 hasConceptScore W2138812066C2781184683 @default.
• W2138812066 hasConceptScore W2138812066C555293320 @default.
• W2138812066 hasConceptScore W2138812066C71924100 @default.
• W2138812066 hasConceptScore W2138812066C77411442 @default.
• W2138812066 hasIssue "4" @default.
• W2138812066 hasLocation W21388120661 @default.
• W2138812066 hasLocation W21388120662 @default.
• W2138812066 hasOpenAccess W2138812066 @default.
• W2138812066 hasPrimaryLocation W21388120661 @default.
• W2138812066 hasRelatedWork W186956879 @default.

• next