Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138814013> ?p ?o ?g. }
- W2138814013 endingPage "5913" @default.
- W2138814013 startingPage "5907" @default.
- W2138814013 abstract "ABSTRACT Iron limitation may cause bacterial pathogens to grow more slowly; however, it may also stimulate these microorganisms to produce greater tissue damage, given that many virulence factors are controlled by the iron supply in the environment. The present study investigated the influence of low iron availability on the expression of proteins and surface sugar residues of two toxigenic strains of Corynebacterium diphtheriae subsp. mitis and evaluated their adherence to human group B erythrocytes and HEp-2 cells. A comparison was made between bacteria grown in (i) Trypticase soy broth (TSB), (ii) TSB treated with dipyridyl to deplete free iron, and (iii) TSB enriched with FeCl 3 . The effects of iron concentration on adhesive properties were different for strains 241 and CDC-E8392, of the sucrose-fermenting and non-sucrose-fermenting biotypes, respectively. Iron-limited conditions enhanced interaction of strain 241 with erythrocytes and HEp-2 cells. Inhibition assays suggested the involvement of nonfimbrial protein combination 67-72p on hemagglutination of diphtheria bacilli grown under iron-limited conditions. Conversely, iron limitation inhibited adherence to glass and expression of electron-dense material on the bacterial surface. Lectin binding assays demonstrated a reduction in the number of sialic acid residues and an increase in d -mannose and d -galactose residues on the surfaces of both strains. Thus, iron exerts a regulatory role on adhesive properties of diphtheria bacilli, and low iron availability modulates the expression of C. diphtheriae surface carbohydrate moieties. The significant changes in the degree of lectin binding specific for d -mannose, d -galactose and sialic acid residues may have an effect on binding of host cells. The expression of dissimilar microbial virulence determinants may be coordinately controlled by common regulatory systems. For C. diphtheriae , the present results imply regulation of adherence and slime production as part of a global response to iron-limited environmental conditions that includes derepression of genes for the synthesis of cytotoxin and siderophores and for transport of the Fe(III)-siderophore complexes." @default.
- W2138814013 created "2016-06-24" @default.
- W2138814013 creator A5018010148 @default.
- W2138814013 creator A5021510091 @default.
- W2138814013 creator A5029855149 @default.
- W2138814013 creator A5033433290 @default.
- W2138814013 creator A5045360377 @default.
- W2138814013 creator A5062484753 @default.
- W2138814013 creator A5063541753 @default.
- W2138814013 creator A5081381090 @default.
- W2138814013 creator A5085150295 @default.
- W2138814013 creator A5089709007 @default.
- W2138814013 date "2003-10-01" @default.
- W2138814013 modified "2023-09-25" @default.
- W2138814013 title "Effects of Iron Limitation on Adherence and Cell Surface Carbohydrates of <i>Corynebacterium diphtheriae</i> Strains" @default.
- W2138814013 cites W1497640343 @default.
- W2138814013 cites W1525417669 @default.
- W2138814013 cites W1871163165 @default.
- W2138814013 cites W1941268961 @default.
- W2138814013 cites W1963029721 @default.
- W2138814013 cites W1973968376 @default.
- W2138814013 cites W1988835900 @default.
- W2138814013 cites W1996095328 @default.
- W2138814013 cites W2005088835 @default.
- W2138814013 cites W2010666762 @default.
- W2138814013 cites W2029930994 @default.
- W2138814013 cites W2039271628 @default.
- W2138814013 cites W2062235018 @default.
- W2138814013 cites W2064069540 @default.
- W2138814013 cites W2073631131 @default.
- W2138814013 cites W2074230856 @default.
- W2138814013 cites W2085285511 @default.
- W2138814013 cites W2100837269 @default.
- W2138814013 cites W2127571689 @default.
- W2138814013 cites W2129779380 @default.
- W2138814013 cites W2149132779 @default.
- W2138814013 cites W2151566970 @default.
- W2138814013 cites W2178477917 @default.
- W2138814013 cites W258376682 @default.
- W2138814013 doi "https://doi.org/10.1128/aem.69.10.5907-5913.2003" @default.
- W2138814013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/201255" @default.
- W2138814013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14532043" @default.
- W2138814013 hasPublicationYear "2003" @default.
- W2138814013 type Work @default.
- W2138814013 sameAs 2138814013 @default.
- W2138814013 citedByCount "56" @default.
- W2138814013 countsByYear W21388140132012 @default.
- W2138814013 countsByYear W21388140132013 @default.
- W2138814013 countsByYear W21388140132014 @default.
- W2138814013 countsByYear W21388140132015 @default.
- W2138814013 countsByYear W21388140132016 @default.
- W2138814013 countsByYear W21388140132017 @default.
- W2138814013 countsByYear W21388140132018 @default.
- W2138814013 countsByYear W21388140132019 @default.
- W2138814013 countsByYear W21388140132020 @default.
- W2138814013 countsByYear W21388140132022 @default.
- W2138814013 crossrefType "journal-article" @default.
- W2138814013 hasAuthorship W2138814013A5018010148 @default.
- W2138814013 hasAuthorship W2138814013A5021510091 @default.
- W2138814013 hasAuthorship W2138814013A5029855149 @default.
- W2138814013 hasAuthorship W2138814013A5033433290 @default.
- W2138814013 hasAuthorship W2138814013A5045360377 @default.
- W2138814013 hasAuthorship W2138814013A5062484753 @default.
- W2138814013 hasAuthorship W2138814013A5063541753 @default.
- W2138814013 hasAuthorship W2138814013A5081381090 @default.
- W2138814013 hasAuthorship W2138814013A5085150295 @default.
- W2138814013 hasAuthorship W2138814013A5089709007 @default.
- W2138814013 hasBestOaLocation W21388140131 @default.
- W2138814013 hasConcept C159047783 @default.
- W2138814013 hasConcept C185592680 @default.
- W2138814013 hasConcept C19655278 @default.
- W2138814013 hasConcept C22070199 @default.
- W2138814013 hasConcept C2775887612 @default.
- W2138814013 hasConcept C2776870249 @default.
- W2138814013 hasConcept C2777911650 @default.
- W2138814013 hasConcept C2778173381 @default.
- W2138814013 hasConcept C2778597767 @default.
- W2138814013 hasConcept C2780115458 @default.
- W2138814013 hasConcept C2780572238 @default.
- W2138814013 hasConcept C2780758401 @default.
- W2138814013 hasConcept C2781288345 @default.
- W2138814013 hasConcept C523546767 @default.
- W2138814013 hasConcept C54355233 @default.
- W2138814013 hasConcept C55493867 @default.
- W2138814013 hasConcept C86803240 @default.
- W2138814013 hasConcept C89423630 @default.
- W2138814013 hasConceptScore W2138814013C159047783 @default.
- W2138814013 hasConceptScore W2138814013C185592680 @default.
- W2138814013 hasConceptScore W2138814013C19655278 @default.
- W2138814013 hasConceptScore W2138814013C22070199 @default.
- W2138814013 hasConceptScore W2138814013C2775887612 @default.
- W2138814013 hasConceptScore W2138814013C2776870249 @default.
- W2138814013 hasConceptScore W2138814013C2777911650 @default.
- W2138814013 hasConceptScore W2138814013C2778173381 @default.
- W2138814013 hasConceptScore W2138814013C2778597767 @default.
- W2138814013 hasConceptScore W2138814013C2780115458 @default.
- W2138814013 hasConceptScore W2138814013C2780572238 @default.
- W2138814013 hasConceptScore W2138814013C2780758401 @default.