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- W2138814771 abstract "NK cells are innate lymphocytes characterized by the expression of nuclear factor interleukin 3 regulated (NFIL3 or E4BP4), eomesodermin (EOMES) transcription factors (TFs), and by the ability to exert cytolytic activity and release IFN-γ. In the haploidentical-hematopoietic stem cell transplantation (haplo-HSCT) setting, CD34+ donor derived NK cells play a major role in the control of leukemic relapses. Therefore, it is important to better define cytokines that influence NK-cell differentiation from CD34+ precursors. We analyzed the effects of IL-1β on NK-cell differentiation from umbilical cord blood (UCB) CD34+ cells. While IL-1β inhibited CD161+CD56+ cell proliferation, an increased expression of LFA-1, CD94/NKG2A, KIRs, and perforin on CD56+ cells was detected. In addition, within the CD161+CD56+IL-1RI+LFA-1− cell fraction (representing group 3 innate lymphoid cells, ILC3-like cells), a significant increase of EOMES, NKp46, and CD94/NKG2A receptors, cytolytic granules, and IFN-γ was detected. This increase was paralleled by a decrease of related orphan receptors (RORγt) TF, NKp44 expression, and IL-22 production. These data suggest that IL-1β inhibits ILC3- while favoring NK-cell maturation. Since in haplo-HSCT conditioning regimen, infections or residual leukemia cells may induce IL-1β production, this may influence the NK/ILC3 development from donor-derived CD34+ precursors." @default.
- W2138814771 created "2016-06-24" @default.
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- W2138814771 date "2015-05-12" @default.
- W2138814771 modified "2023-10-07" @default.
- W2138814771 title "IL-1β inhibits ILC3 while favoring NK-cell maturation of umbilical cord blood CD34<sup>+</sup>precursors" @default.
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- W2138814771 doi "https://doi.org/10.1002/eji.201445326" @default.
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