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- W2138822307 endingPage "170" @default.
- W2138822307 startingPage "133" @default.
- W2138822307 abstract "The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an invariant core complex, composed of the Skp1 linker protein, the Cdc53/Cul1 scaffold protein and the Rbx1/Roc1/Hrt1 RING domain protein, engages one of a suite of substrate adaptors called F-box proteins that in turn recruit substrates for ubiquitination by an associated E2 enzyme. The cullin–RING domain–adaptor architecture has diversified through evolution, such that in total many hundreds of distinct SCF and SCF-like complexes enable degradation of myriad substrates. Substrate recognition by adaptors often depends on posttranslational modification of the substrate, which thus places substrate stability under dynamic regulation by intracellular signaling events. SCF complexes control cell proliferation through degradation of critical regulators such as cyclins, CDK inhibitors and transcription factors. A plethora of other processes in development and disease are controlled by other SCF-like complexes, including those based on Cul2–SOCS-box adaptor protein and Cul3–BTB domain adaptor protein combinations. Recent structural insights into SCF-like complexes have begun to illuminate aspects of substrate recognition and catalytic reaction mechanisms." @default.
- W2138822307 created "2016-06-24" @default.
- W2138822307 creator A5031352602 @default.
- W2138822307 creator A5044806399 @default.
- W2138822307 creator A5057700057 @default.
- W2138822307 date "2004-11-01" @default.
- W2138822307 modified "2023-10-11" @default.
- W2138822307 title "A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin" @default.
- W2138822307 cites W130301589 @default.
- W2138822307 cites W1487147936 @default.
- W2138822307 cites W1493317669 @default.
- W2138822307 cites W1500827124 @default.
- W2138822307 cites W1501553911 @default.
- W2138822307 cites W1506793089 @default.
- W2138822307 cites W1514273943 @default.
- W2138822307 cites W1527149712 @default.
- W2138822307 cites W1530194480 @default.
- W2138822307 cites W1531957421 @default.
- W2138822307 cites W1538028541 @default.
- W2138822307 cites W1538085254 @default.
- W2138822307 cites W1544401280 @default.
- W2138822307 cites W1552046925 @default.
- W2138822307 cites W1557900165 @default.
- W2138822307 cites W1558846872 @default.
- W2138822307 cites W1573825647 @default.
- W2138822307 cites W1574375290 @default.
- W2138822307 cites W1580962701 @default.
- W2138822307 cites W1581255397 @default.
- W2138822307 cites W1588637161 @default.
- W2138822307 cites W1589070815 @default.
- W2138822307 cites W172411893 @default.
- W2138822307 cites W1769736739 @default.
- W2138822307 cites W1778446120 @default.
- W2138822307 cites W1832030339 @default.
- W2138822307 cites W1852163795 @default.
- W2138822307 cites W1888823860 @default.
- W2138822307 cites W1897326544 @default.
- W2138822307 cites W1907693116 @default.
- W2138822307 cites W1945732560 @default.
- W2138822307 cites W1958512987 @default.
- W2138822307 cites W1963533810 @default.
- W2138822307 cites W1964517213 @default.
- W2138822307 cites W1964827998 @default.
- W2138822307 cites W1965077784 @default.
- W2138822307 cites W1965863607 @default.
- W2138822307 cites W1966034049 @default.
- W2138822307 cites W1966522270 @default.
- W2138822307 cites W1966848901 @default.
- W2138822307 cites W1967163876 @default.
- W2138822307 cites W1967544564 @default.
- W2138822307 cites W1967579846 @default.
- W2138822307 cites W1967972966 @default.
- W2138822307 cites W1968495382 @default.
- W2138822307 cites W1968841865 @default.
- W2138822307 cites W1969210627 @default.
- W2138822307 cites W1969434750 @default.
- W2138822307 cites W1970078605 @default.
- W2138822307 cites W1970779989 @default.
- W2138822307 cites W1971034699 @default.
- W2138822307 cites W1971819775 @default.
- W2138822307 cites W1972139510 @default.
- W2138822307 cites W1972542025 @default.
- W2138822307 cites W1972780353 @default.
- W2138822307 cites W1973092951 @default.
- W2138822307 cites W1973564464 @default.
- W2138822307 cites W1975331444 @default.
- W2138822307 cites W1976449876 @default.
- W2138822307 cites W1976874039 @default.
- W2138822307 cites W1977290507 @default.
- W2138822307 cites W1977340592 @default.
- W2138822307 cites W1977632922 @default.
- W2138822307 cites W1977647141 @default.
- W2138822307 cites W1981849277 @default.
- W2138822307 cites W1982186905 @default.
- W2138822307 cites W1982290796 @default.
- W2138822307 cites W1983222046 @default.
- W2138822307 cites W1983349903 @default.
- W2138822307 cites W1983724235 @default.
- W2138822307 cites W1984012038 @default.
- W2138822307 cites W1985212818 @default.
- W2138822307 cites W1985225337 @default.
- W2138822307 cites W1985233399 @default.
- W2138822307 cites W1985476964 @default.
- W2138822307 cites W1986384364 @default.
- W2138822307 cites W1986557026 @default.
- W2138822307 cites W1986917337 @default.
- W2138822307 cites W1986986406 @default.
- W2138822307 cites W1987623929 @default.
- W2138822307 cites W1988780457 @default.
- W2138822307 cites W1989088998 @default.
- W2138822307 cites W1989382065 @default.
- W2138822307 cites W1989443663 @default.
- W2138822307 cites W1990368851 @default.
- W2138822307 cites W1990834064 @default.
- W2138822307 cites W1991930087 @default.
- W2138822307 cites W1991930213 @default.
- W2138822307 cites W1992798036 @default.
- W2138822307 cites W1994196743 @default.