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- W2138822559 abstract "Die LD50 von Endomid (1) und von fünf seiner Metaboliten 2–6 wurde an der Maus bestimmt. Die Toxizität nimmt in der Reihenfolge von 1 bis 6 kontinuierlich ab, eine potentielle Gefahr als Folge der Metabolisierung kann daher ausgeschlossen werden. Die Löslichkeit, der n-Octanol/Wasser-Verteilungskoeffizient, der RM-Wert und die Permeationsgeschwindigkeit in einem In-vitro-Resorptionsmodell von 1–6 wurden bestimmt und zur biologischen Aktivität in Beziehung gesetzt. Acute Toxicity of Endomide and Its Metabolites. Correlation between Biological Activity and Lipophilic Properties The medium letal doses of endomide (1) and of five of its metabolites 2–6 have been estimated in the mouse. Toxicity decreases from 1 to 6. A risk as a consequence of metabolization can thus be excluded. The solubilities, the n-Octanol/water partition coefficients, the RM values and the permeation rates in an in vitro absorption model have been estimated for 1–6 and put into relation with the biological activities." @default.
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- W2138822559 date "1976-01-01" @default.
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- W2138822559 title "Akute Toxizität von Endomid® und seinen Metaboliten. Korrelation zwischen biologischer Aktivität und lipophilen Eigenschaften" @default.
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- W2138822559 doi "https://doi.org/10.1002/ardp.19763091008" @default.
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