FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138823142> ?p ?o ?g. }

• W2138823142 endingPage "664" @default.
• W2138823142 startingPage "653" @default.
• W2138823142 abstract "The majority of women diagnosed with epithelial ovarian carcinoma (EOC) succumb due to complications of metastatic disease, suggesting that antimetastatic therapies may improve patient survival. EOC metastasis involves intraperitoneal shedding of cells from the primary tumor, followed by adhesion and localized penetration of the submesothelial matrix to anchor metastatic implants. Accumulation of malignant ascites is also common. Thus, a unique microenvironmental niche is established, which includes malignant cells and a plethora of soluble factors secreted by-or in response to-tumor cells. As cells penetrating the submesothelial surface encounter an interstitial collagen-rich extracellular matrix, we have used three-dimensional type I collagen gels to model early events resulting from intraperitoneal anchoring. In this study, we show a novel pathway of CXCR4 upregulation through beta1 integrin - and NFkappaB-dependent signaling pathways in response to three-dimensional type I collagen. We also show the involvement of CXCR4-SDF1 axis in collagen invasion and proliferation, relevant to the metastatic EOC. Our data show that CXCR4 expression in human EOCs, as well as SDF1 presence in the ascites, is correlated with disease progression and metastasis. These data emphasize the importance of the CXCR4-SDF1 axis in EOC metastasis and suggest that this mechanism should be accounted for when targeting EOC metastasis." @default.
• W2138823142 created "2016-06-24" @default.
• W2138823142 creator A5033401304 @default.
• W2138823142 creator A5034090671 @default.
• W2138823142 creator A5061375376 @default.
• W2138823142 creator A5061824879 @default.
• W2138823142 creator A5065417262 @default.
• W2138823142 creator A5076601561 @default.
• W2138823142 creator A5083516725 @default.
• W2138823142 creator A5084265608 @default.
• W2138823142 date "2010-05-01" @default.
• W2138823142 modified "2023-10-18" @default.
• W2138823142 title "Microenvironmental Regulation of Chemokine (C-X-C-Motif) Receptor 4 in Ovarian Carcinoma" @default.
• W2138823142 cites W1547623660 @default.
• W2138823142 cites W1548997088 @default.
• W2138823142 cites W1594207045 @default.
• W2138823142 cites W168898604 @default.
• W2138823142 cites W1963592300 @default.
• W2138823142 cites W1965587103 @default.
• W2138823142 cites W1974634396 @default.
• W2138823142 cites W1977222310 @default.
• W2138823142 cites W1979337120 @default.
• W2138823142 cites W1980790180 @default.
• W2138823142 cites W1983202862 @default.
• W2138823142 cites W1985662208 @default.
• W2138823142 cites W1986986419 @default.
• W2138823142 cites W1989035987 @default.
• W2138823142 cites W1992035698 @default.
• W2138823142 cites W1992767716 @default.
• W2138823142 cites W1998276951 @default.
• W2138823142 cites W2002495982 @default.
• W2138823142 cites W2009021998 @default.
• W2138823142 cites W2012542405 @default.
• W2138823142 cites W2023624246 @default.
• W2138823142 cites W2027284511 @default.
• W2138823142 cites W2032868540 @default.
• W2138823142 cites W2041766504 @default.
• W2138823142 cites W2047763902 @default.
• W2138823142 cites W2051467321 @default.
• W2138823142 cites W2054989216 @default.
• W2138823142 cites W2055536127 @default.
• W2138823142 cites W2059196682 @default.
• W2138823142 cites W2061911579 @default.
• W2138823142 cites W2077021879 @default.
• W2138823142 cites W2080303025 @default.
• W2138823142 cites W2093170084 @default.
• W2138823142 cites W2098275650 @default.
• W2138823142 cites W2101037339 @default.
• W2138823142 cites W2107277218 @default.
• W2138823142 cites W2108381748 @default.
• W2138823142 cites W2123643395 @default.
• W2138823142 cites W2123782854 @default.
• W2138823142 cites W2130117660 @default.
• W2138823142 cites W2138788396 @default.
• W2138823142 cites W2144414931 @default.
• W2138823142 cites W2145263546 @default.
• W2138823142 cites W2156323704 @default.
• W2138823142 cites W2162526893 @default.
• W2138823142 cites W2324992364 @default.
• W2138823142 cites W2352404391 @default.
• W2138823142 cites W4234772783 @default.
• W2138823142 cites W4243605909 @default.
• W2138823142 doi "https://doi.org/10.1158/1541-7786.mcr-09-0463" @default.
• W2138823142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2883461" @default.
• W2138823142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20460402" @default.
• W2138823142 hasPublicationYear "2010" @default.
• W2138823142 type Work @default.
• W2138823142 sameAs 2138823142 @default.
• W2138823142 citedByCount "51" @default.
• W2138823142 countsByYear W21388231422012 @default.
• W2138823142 countsByYear W21388231422013 @default.
• W2138823142 countsByYear W21388231422014 @default.
• W2138823142 countsByYear W21388231422015 @default.
• W2138823142 countsByYear W21388231422016 @default.
• W2138823142 countsByYear W21388231422017 @default.
• W2138823142 countsByYear W21388231422018 @default.
• W2138823142 countsByYear W21388231422019 @default.
• W2138823142 countsByYear W21388231422020 @default.
• W2138823142 countsByYear W21388231422021 @default.
• W2138823142 countsByYear W21388231422022 @default.
• W2138823142 crossrefType "journal-article" @default.
• W2138823142 hasAuthorship W2138823142A5033401304 @default.
• W2138823142 hasAuthorship W2138823142A5034090671 @default.
• W2138823142 hasAuthorship W2138823142A5061375376 @default.
• W2138823142 hasAuthorship W2138823142A5061824879 @default.
• W2138823142 hasAuthorship W2138823142A5065417262 @default.
• W2138823142 hasAuthorship W2138823142A5076601561 @default.
• W2138823142 hasAuthorship W2138823142A5083516725 @default.
• W2138823142 hasAuthorship W2138823142A5084265608 @default.
• W2138823142 hasBestOaLocation W21388231421 @default.
• W2138823142 hasConcept C121608353 @default.
• W2138823142 hasConcept C126322002 @default.
• W2138823142 hasConcept C12823836 @default.
• W2138823142 hasConcept C129470790 @default.
• W2138823142 hasConcept C13373296 @default.
• W2138823142 hasConcept C142724271 @default.
• W2138823142 hasConcept C170493617 @default.
• W2138823142 hasConcept C189165786 @default.

• next