Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138824420> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2138824420 endingPage "556" @default.
- W2138824420 startingPage "553" @default.
- W2138824420 abstract "Chronic anal fissure has traditionally been treated surgically. Initial enthusiasm for chemical sphincterotomy has waned because of poor outcomes with glyceryl trinitrate ointment. In this study the use of topical 2 per cent diltiazem ointment has been investigated as an alternative method of chemical sphincterotomy.A prospective assessment of 71 consecutive patients with a chronic anal fissure treated with 2 per cent topical diltiazem ointment for a median duration of 9 (range 2--16) weeks was performed.Fifty-one patients (75 per cent) experienced healing of the fissure after 2--3 months of treatment with topical diltiazem. Seventeen patients who did not heal were treated for a further 8 weeks with topical diltiazem. Eight of these patients subsequently healed with diltiazem. Fifty-nine of 67 patients who completed follow-up therefore healed on diltiazem ointment. Four patients experienced perianal dermatitis and one patient experienced headaches. No other side-effects were recorded. After a median of 32 (range 14--67) weeks' follow-up following completion of treatment, 27 of 41 patients available remain symptom free. Six of seven patients with recurrent fissure were treated successfully by repeat chemical sphincterotomy.Topical 2 per cent diltiazem ointment used as an agent for chemical sphincterotomy for chronic anal fissure offers significant healing rates but does not have a significant side-effect profile, which may aid compliance to treatment. Early recurrences are common but usually amenable to further chemical sphincterotomy." @default.
- W2138824420 created "2016-06-24" @default.
- W2138824420 creator A5006748864 @default.
- W2138824420 creator A5041469161 @default.
- W2138824420 creator A5071754168 @default.
- W2138824420 date "2001-04-01" @default.
- W2138824420 modified "2023-10-14" @default.
- W2138824420 title "Topical diltiazem ointment in the treatment of chronic anal fissure" @default.
- W2138824420 cites W1969184876 @default.
- W2138824420 cites W1975901734 @default.
- W2138824420 cites W1977075287 @default.
- W2138824420 cites W2011903618 @default.
- W2138824420 cites W2014276885 @default.
- W2138824420 cites W2017154221 @default.
- W2138824420 cites W2022811299 @default.
- W2138824420 cites W2024116901 @default.
- W2138824420 cites W2060330546 @default.
- W2138824420 cites W2084924890 @default.
- W2138824420 cites W2096837520 @default.
- W2138824420 cites W2125286641 @default.
- W2138824420 cites W2138778828 @default.
- W2138824420 cites W2145850304 @default.
- W2138824420 doi "https://doi.org/10.1046/j.1365-2168.2001.01736.x" @default.
- W2138824420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11298624" @default.
- W2138824420 hasPublicationYear "2001" @default.
- W2138824420 type Work @default.
- W2138824420 sameAs 2138824420 @default.
- W2138824420 citedByCount "128" @default.
- W2138824420 countsByYear W21388244202012 @default.
- W2138824420 countsByYear W21388244202013 @default.
- W2138824420 countsByYear W21388244202014 @default.
- W2138824420 countsByYear W21388244202015 @default.
- W2138824420 countsByYear W21388244202016 @default.
- W2138824420 countsByYear W21388244202017 @default.
- W2138824420 countsByYear W21388244202018 @default.
- W2138824420 countsByYear W21388244202019 @default.
- W2138824420 countsByYear W21388244202020 @default.
- W2138824420 countsByYear W21388244202021 @default.
- W2138824420 countsByYear W21388244202022 @default.
- W2138824420 countsByYear W21388244202023 @default.
- W2138824420 crossrefType "journal-article" @default.
- W2138824420 hasAuthorship W2138824420A5006748864 @default.
- W2138824420 hasAuthorship W2138824420A5041469161 @default.
- W2138824420 hasAuthorship W2138824420A5071754168 @default.
- W2138824420 hasConcept C126322002 @default.
- W2138824420 hasConcept C141071460 @default.
- W2138824420 hasConcept C2776741139 @default.
- W2138824420 hasConcept C2776967484 @default.
- W2138824420 hasConcept C42219234 @default.
- W2138824420 hasConcept C519063684 @default.
- W2138824420 hasConcept C71924100 @default.
- W2138824420 hasConceptScore W2138824420C126322002 @default.
- W2138824420 hasConceptScore W2138824420C141071460 @default.
- W2138824420 hasConceptScore W2138824420C2776741139 @default.
- W2138824420 hasConceptScore W2138824420C2776967484 @default.
- W2138824420 hasConceptScore W2138824420C42219234 @default.
- W2138824420 hasConceptScore W2138824420C519063684 @default.
- W2138824420 hasConceptScore W2138824420C71924100 @default.
- W2138824420 hasIssue "4" @default.
- W2138824420 hasLocation W21388244201 @default.
- W2138824420 hasLocation W21388244202 @default.
- W2138824420 hasOpenAccess W2138824420 @default.
- W2138824420 hasPrimaryLocation W21388244201 @default.
- W2138824420 hasRelatedWork W2002120878 @default.
- W2138824420 hasRelatedWork W2003938723 @default.
- W2138824420 hasRelatedWork W2047967234 @default.
- W2138824420 hasRelatedWork W2063740574 @default.
- W2138824420 hasRelatedWork W2118496982 @default.
- W2138824420 hasRelatedWork W2364998975 @default.
- W2138824420 hasRelatedWork W2439875401 @default.
- W2138824420 hasRelatedWork W4238867864 @default.
- W2138824420 hasRelatedWork W2519357708 @default.
- W2138824420 hasRelatedWork W2525756941 @default.
- W2138824420 hasVolume "88" @default.
- W2138824420 isParatext "false" @default.
- W2138824420 isRetracted "false" @default.
- W2138824420 magId "2138824420" @default.
- W2138824420 workType "article" @default.