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- W2138825478 abstract "Activity-dependent changes in the short-term electrical properties of neurites were investigated in the anterior pagoda (AP) cell of leech. Imaging studies revealed that backpropagating Na + spikes and synaptically evoked EPSPs caused Ca 2+ entry through low-voltage-activated Ca 2+ channels that are distributed throughout the neurites. Voltage-clamp recordings from the soma revealed a TEA-sensitive outward current that was reduced when Ca 2+ entry was blocked with Co 2+ or when the intracellular concentration of free Ca 2+ was reduced by a high-affinity Ca 2+ buffer. Ca 2+ released in the neurite from a caged Ca 2+ compound caused a hyperpolarization of the membrane potential. These data imply that the AP cell expresses Ca 2+ -activated K + conductances, and that these conductances are present in the neurites. When the Ca 2+ -activated K + current was reduced through the block of Ca 2+ entry, backpropagating Na + spikes and synaptically evoked EPSPs increased in amplitude. Hence, the activity-dependent changes in the intracellular [Ca 2+ ] together with the Ca 2+ -activated K + conductances participate in the regulation of dendritic signal propagation." @default.
- W2138825478 created "2016-06-24" @default.
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- W2138825478 date "1999-10-01" @default.
- W2138825478 modified "2023-10-12" @default.
- W2138825478 title "Dendritic Ca2+-Activated K+Conductances Regulate Electrical Signal Propagation in an Invertebrate Neuron" @default.
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- W2138825478 doi "https://doi.org/10.1523/jneurosci.19-19-08319.1999" @default.
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