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• W2138825500 abstract "Cells exposed to reactive oxygen species will incur a range of genetic aberrations, which may either be structural (e.g. deletion. DNA strand breaks) or numerical (e.g. chromosomal loss/ gain). Some studies suggest that chromosome 11 contains loci which prevent the induction of chromosomal aberrations by reactive oxygen species. For example, the insertion of an extra chromosome 11 into bladder carcinoma cells decreases the frequency of micronuclei (index of chromosomal damage) induced by hydrogen peroxide and X-rays. The development of fluorescence in situ hybridization (FISH) facilitates studies exploring the significance of numerical chromosomal aberrations in carcinogenesis. In this study, the hypothesis tested was that chromosome 1 1 insertion protects against numerical chromosomal changes induced by hydrogen peroxide and X-rays. The level of chromosome loss and gain were assayed with the FISH technique, which allows the determination of chromosome number in interphase cells. Peroxide treatment induced numerical chromosome alterations, but neither chromosome loss nor gain was significantly different between the parent and hybrid cell cultures. X-irradiating cells a t 0-2 Gy did not result in significant chromosomal number changes in either cell cultures, in spite of the fact that a dose of 2 Gy induced large numbers of micronucleated cells. Further investigation exposed parent cells to higher X-ray doses (0-4 Gy) and to a range of time intervals between irradiation and cell harvesting. These variations yielded significant chromosome gains, but not losses. The apparent gain in chromosomes without a corresponding loss points to the possibility of a fragile FISH target region. In summary, the results of this thesis suggest that (1) the insertion of an extra chromosome 11 does not protect against numerical chromosomal aberrations induced by hydrogen peroxide, and (2) levels of X-rays which induce high levels of structural chromosomal damage (micronuclei) fail to induce significant levels of numerical chromosomal aberrations." @default.
• W2138825500 created "2016-06-24" @default.
• W2138825500 creator A5070691632 @default.
• W2138825500 date "1995-01-01" @default.
• W2138825500 modified "2023-09-27" @default.
• W2138825500 title "Induction of numerical chromosomal aberrations by reactive oxygen species" @default.
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