FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138826259> ?p ?o ?g. }

• W2138826259 endingPage "1306" @default.
• W2138826259 startingPage "1297" @default.
• W2138826259 abstract "To investigate the role of hTERT gene expression and AP-2α in n-butylidenephthalide (n-BP)-induced apoptosis in A549 lung cancer cells. Viability of A549 cells was measured by MTT assay. Protein expression was determined by Western blot. Telomerase activity was measured using the modified telomere repeat amplification protocol (TRAP) assay. Xenograft mice were used as a model system to study the cytotoxic effect of n-BP in vivo. The morphology of tumor was examined by immunohistochemical staining. The growth of A549 lung cancer cells treated with n-BP was significantly inhibited. Telomerase activity and hTERT mRNA expression were determined by telomeric repeat amplification protocol and reverse transcription-polymerase chain reaction, respectively. n-BP inhibited telomerase activity and hTERT mRNA expression in A549 cells while overexpression of hTERT could abolish BP-induced growth inhibition in the A549 cells. We also showed that hTERT promoter activity in the presence of n-BP was mediated via AP-2α. We saw an inhibition of tumor growth when nude mice carrying A549 subcutaneous xenograft tumors were treated with n-BP. Immunohistochemistry of this tumor tissue also showed a decrease in the expression of hTERT. The antiproliferative effects of n-BP on A549 cells in vitro and in vivo suggest a novel clinical application of this compound in the treatment of lung cancers." @default.
• W2138826259 created "2016-06-24" @default.
• W2138826259 creator A5001730010 @default.
• W2138826259 creator A5002098911 @default.
• W2138826259 creator A5021898832 @default.
• W2138826259 creator A5048585649 @default.
• W2138826259 creator A5062595657 @default.
• W2138826259 creator A5064142881 @default.
• W2138826259 creator A5066150223 @default.
• W2138826259 creator A5069894624 @default.
• W2138826259 creator A5075133537 @default.
• W2138826259 creator A5078451413 @default.
• W2138826259 creator A5084580787 @default.
• W2138826259 date "2009-08-24" @default.
• W2138826259 modified "2023-10-03" @default.
• W2138826259 title "n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2α and telomerase activity" @default.
• W2138826259 cites W1677751641 @default.
• W2138826259 cites W1964228845 @default.
• W2138826259 cites W1984253873 @default.
• W2138826259 cites W1986636337 @default.
• W2138826259 cites W1998839615 @default.
• W2138826259 cites W1999502149 @default.
• W2138826259 cites W2000971601 @default.
• W2138826259 cites W2001568938 @default.
• W2138826259 cites W2010956784 @default.
• W2138826259 cites W2026856852 @default.
• W2138826259 cites W2029421262 @default.
• W2138826259 cites W2030954212 @default.
• W2138826259 cites W2038883360 @default.
• W2138826259 cites W2045702252 @default.
• W2138826259 cites W2049672603 @default.
• W2138826259 cites W2059768085 @default.
• W2138826259 cites W2062395030 @default.
• W2138826259 cites W2066002720 @default.
• W2138826259 cites W2069744703 @default.
• W2138826259 cites W2074108393 @default.
• W2138826259 cites W2079378073 @default.
• W2138826259 cites W2081928213 @default.
• W2138826259 cites W2086132669 @default.
• W2138826259 cites W2087459085 @default.
• W2138826259 cites W2093867005 @default.
• W2138826259 cites W2108442086 @default.
• W2138826259 cites W2115443599 @default.
• W2138826259 cites W2117090314 @default.
• W2138826259 cites W2117548412 @default.
• W2138826259 cites W2125455937 @default.
• W2138826259 cites W2137064925 @default.
• W2138826259 cites W2139151268 @default.
• W2138826259 cites W2146753152 @default.
• W2138826259 cites W2154686348 @default.
• W2138826259 cites W2169455407 @default.
• W2138826259 cites W2331040770 @default.
• W2138826259 cites W4237540956 @default.
• W2138826259 doi "https://doi.org/10.1038/aps.2009.124" @default.
• W2138826259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4007174" @default.
• W2138826259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19701232" @default.
• W2138826259 hasPublicationYear "2009" @default.
• W2138826259 type Work @default.
• W2138826259 sameAs 2138826259 @default.
• W2138826259 citedByCount "49" @default.
• W2138826259 countsByYear W21388262592012 @default.
• W2138826259 countsByYear W21388262592013 @default.
• W2138826259 countsByYear W21388262592014 @default.
• W2138826259 countsByYear W21388262592015 @default.
• W2138826259 countsByYear W21388262592016 @default.
• W2138826259 countsByYear W21388262592017 @default.
• W2138826259 countsByYear W21388262592018 @default.
• W2138826259 countsByYear W21388262592019 @default.
• W2138826259 countsByYear W21388262592020 @default.
• W2138826259 countsByYear W21388262592021 @default.
• W2138826259 countsByYear W21388262592022 @default.
• W2138826259 countsByYear W21388262592023 @default.
• W2138826259 crossrefType "journal-article" @default.
• W2138826259 hasAuthorship W2138826259A5001730010 @default.
• W2138826259 hasAuthorship W2138826259A5002098911 @default.
• W2138826259 hasAuthorship W2138826259A5021898832 @default.
• W2138826259 hasAuthorship W2138826259A5048585649 @default.
• W2138826259 hasAuthorship W2138826259A5062595657 @default.
• W2138826259 hasAuthorship W2138826259A5064142881 @default.
• W2138826259 hasAuthorship W2138826259A5066150223 @default.
• W2138826259 hasAuthorship W2138826259A5069894624 @default.
• W2138826259 hasAuthorship W2138826259A5075133537 @default.
• W2138826259 hasAuthorship W2138826259A5078451413 @default.
• W2138826259 hasAuthorship W2138826259A5084580787 @default.
• W2138826259 hasBestOaLocation W21388262591 @default.
• W2138826259 hasConcept C104317684 @default.
• W2138826259 hasConcept C125593758 @default.
• W2138826259 hasConcept C150903083 @default.
• W2138826259 hasConcept C153911025 @default.
• W2138826259 hasConcept C185592680 @default.
• W2138826259 hasConcept C190283241 @default.
• W2138826259 hasConcept C207001950 @default.
• W2138826259 hasConcept C2776415932 @default.
• W2138826259 hasConcept C2780783641 @default.
• W2138826259 hasConcept C502942594 @default.
• W2138826259 hasConcept C54355233 @default.
• W2138826259 hasConcept C55493867 @default.
• W2138826259 hasConcept C81729549 @default.

• next