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• W2138826360 abstract "Functional CD8 T cell effector and memory responses are generated and maintained during murine γ-herpesvirus 68 (γHV68) persistent infection despite continuous presentation of viral lytic Ags. However, the identity of the CD8 T cell subpopulations that mediate effective recall responses and that can participate in the generation of protective memory to a γ-herpesvirus infection remains unknown. During γHV68 persistence, ∼75% of γHV68-specific CD8 T cells coexpress the NK receptors killer cell lectin-like receptor G1 (KLRG1) and NKG2A. In this study, we take advantage of this unique phenotype to analyze the capacity of CD8 T cells expressing or not expressing KLRG1 and NKG2A to mediate effector and memory responses. Our results show that γHV68-specific KLRG1(+)NKG2A(+) CD8 T cells have an effector memory phenotype as well as characteristics of polyfunctional effector cells such us IFN-γ and TNF-α production, killing capacity, and are more efficient at protecting against a γHV68 challenge than their NKG2A(-)KLRG1(-) counterparts. Nevertheless, γHV68-specific NKG2A(+)KLRG1(+) CD8 T cells express IL-7 and IL-15 receptors, can survive long-term without cognate Ag, and subsequently mount a protective response during antigenic recall. These results highlight the plasticity of the immune system to generate protective effector and proliferative memory responses during virus persistence from a pool of KLRG1(+)NKG2A(+) effector memory CD8 T cells." @default.
• W2138826360 created "2016-06-24" @default.
• W2138826360 creator A5006232335 @default.
• W2138826360 creator A5054946519 @default.
• W2138826360 date "2011-04-01" @default.
• W2138826360 modified "2023-10-16" @default.
• W2138826360 title "KLRG1+NKG2A+ CD8 T Cells Mediate Protection and Participate in Memory Responses during γ-Herpesvirus Infection" @default.
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• W2138826360 doi "https://doi.org/10.4049/jimmunol.1003122" @default.
• W2138826360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3153874" @default.
• W2138826360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21346231" @default.
• W2138826360 hasPublicationYear "2011" @default.
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