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• W2138827290 abstract "Due to the anticancer properties of bleomycin (BLM) complexes, production of ( 103 Pd)bleomycin (( 103 Pd)BLM) was targeted. Palladium-103 (T1/2 = 16.96 d) was produced via the 103 Rh(p,n) 103 Pd nuclear reaction using a natural rhodium target. Proton energy was 18 MeV with 200 µA irradiation for 15 h (final activity 25.9 GBq of 103 Pd 2+ , RCP > 95%, radionuclidic purity > 99%). 103 Pd was separated from the irradiated target by anion exchange using a Dowex 1× 8 (Cl − )/100−200 mesh resin in the form of Pd(NH3)2Cl2 in order to react with bleomycin to yield ( 103 Pd)BLM. Chemical purity of the final product was in accordance to the accepted limits. ( 103 Pd)BLM was prepared with a radiochemical yield of more than 98% at 80°C in 30 min. The labeling reaction was optimized for time, temperature and ligand concentration. Radiochemical purity of more than 99% was obtained using RTLC with specific activity of about 370 MBq/mmol. The stability of the tracer was checked in the final product and presence of human serum at up to 3 h. The complex was stable in human serum at 37°C up to 2 h of incubation. Biodistribution studies using a SPECT system performed in normal rats in the first 2−3 h." @default.
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• W2138827290 date "2006-01-01" @default.
• W2138827290 modified "2023-09-27" @default.
• W2138827290 title "Production of ( 103 Pd)Bleomycin complex for targeted therapy" @default.
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