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• W2138828060 abstract "Lanthanide Eu3+ and Tb3+ ions have been widely used in luminescent resonance energy transfer (LRET) for bioassays to study metal binding microenvironments. We report here that Eu3+ or Tb3+ can increase the binding affinity of antitumor antibiotic drug agent, 7-amino actinomycin D (7AACTD), binding to 5′-GT/TG-5′ or 5′-GA/AG-5′ mismatched stem region of the single-stranded hairpin DNA. Further studies indicate that the effect of Eu3+ or Tb3+ on 7AACTD binding is related to DNA loop sequence. Our results will provide new insights into how metal ions can enhance antitumor agents binding to their targets." @default.
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• W2138828060 date "2009-12-01" @default.
• W2138828060 modified "2023-10-17" @default.
• W2138828060 title "7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu3+ and Tb3+ binding" @default.
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• W2138828060 doi "https://doi.org/10.1016/j.jinorgbio.2009.09.010" @default.
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