FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138829885> ?p ?o ?g. }

• W2138829885 abstract "The giant panda (Ailuropoda melanoleuca) is one of the most endangered animals due to habitat fragmentation and loss. Although the captive breeding program for this species is now nearly two decades old, researches on the genetic background of such captive populations, especially on adaptive molecular polymorphism of major histocompatibility complex (MHC), are still limited. In this study, we characterized adaptive variation of the giant panda's MHC DQA gene by PCR amplification of its antigen-recognizing region (i.e. the exon 2) and subsequent single-strand conformational polymorphism (SSCP) and sequence analyses.The results revealed a low level of DQA exon 2 diversity in this rare animal, presenting 6 alleles from 61 giant panda individuals. The observed polymorphism was restricted to 9 amino acid substitutions, all of which occurred at and adjacent to positions forming the functionally important antigen-binding sites. All the samples were in Hardy-Weinberg proportions. A significantly higher rate of non-synonymous than synonymous substitutions at the antigen-binding sites indicated positive selection for diversity in the locus.The DQA allelic diversity of giant pandas was low relative to other vertebrates. Nonetheless, the pandas exhibited more alleles in DQA than those in DRB, suggesting the alpha chain genes would play a leading role when coping with certain pathogens and thus should be included in conservation genetic investigation. The microsatellite and MHC loci might predict long-term persistence potential and short-term survival ability, respectively. Consequently, it is recommended to utilize multiple suites of microsatellite markers and multiple MHC loci to detect overall genetic variation in order to design unbiased conservation strategies." @default.
• W2138829885 created "2016-06-24" @default.
• W2138829885 creator A5011671209 @default.
• W2138829885 creator A5033781594 @default.
• W2138829885 creator A5048180745 @default.
• W2138829885 creator A5072910440 @default.
• W2138829885 creator A5087741712 @default.
• W2138829885 date "2007-06-07" @default.
• W2138829885 modified "2023-10-16" @default.
• W2138829885 title "Low major histocompatibility complex class II DQA diversity in the Giant Panda (Ailuropoda melanoleuca)" @default.
• W2138829885 cites W1554848273 @default.
• W2138829885 cites W1652383174 @default.
• W2138829885 cites W1935763178 @default.
• W2138829885 cites W1975827366 @default.
• W2138829885 cites W1977174195 @default.
• W2138829885 cites W1984339309 @default.
• W2138829885 cites W1990719254 @default.
• W2138829885 cites W2004669462 @default.
• W2138829885 cites W2014689109 @default.
• W2138829885 cites W2015921598 @default.
• W2138829885 cites W2030140902 @default.
• W2138829885 cites W2032897072 @default.
• W2138829885 cites W2056384440 @default.
• W2138829885 cites W2080956086 @default.
• W2138829885 cites W2087383801 @default.
• W2138829885 cites W2093245190 @default.
• W2138829885 cites W2101049864 @default.
• W2138829885 cites W2124769272 @default.
• W2138829885 cites W2138361561 @default.
• W2138829885 cites W2142538655 @default.
• W2138829885 cites W2150891192 @default.
• W2138829885 cites W2156434383 @default.
• W2138829885 cites W2157285699 @default.
• W2138829885 cites W2157764447 @default.
• W2138829885 cites W2160327332 @default.
• W2138829885 cites W2164928863 @default.
• W2138829885 cites W2169240313 @default.
• W2138829885 cites W2184418667 @default.
• W2138829885 cites W2188653781 @default.
• W2138829885 cites W2253414912 @default.
• W2138829885 cites W2265101243 @default.
• W2138829885 cites W2360847425 @default.
• W2138829885 cites W4229803116 @default.
• W2138829885 cites W4367169726 @default.
• W2138829885 cites W93588716 @default.
• W2138829885 doi "https://doi.org/10.1186/1471-2156-8-29" @default.
• W2138829885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904234" @default.
• W2138829885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17555583" @default.
• W2138829885 hasPublicationYear "2007" @default.
• W2138829885 type Work @default.
• W2138829885 sameAs 2138829885 @default.
• W2138829885 citedByCount "22" @default.
• W2138829885 countsByYear W21388298852012 @default.
• W2138829885 countsByYear W21388298852013 @default.
• W2138829885 countsByYear W21388298852014 @default.
• W2138829885 countsByYear W21388298852015 @default.
• W2138829885 countsByYear W21388298852017 @default.
• W2138829885 countsByYear W21388298852018 @default.
• W2138829885 countsByYear W21388298852019 @default.
• W2138829885 countsByYear W21388298852020 @default.
• W2138829885 countsByYear W21388298852021 @default.
• W2138829885 countsByYear W21388298852023 @default.
• W2138829885 crossrefType "journal-article" @default.
• W2138829885 hasAuthorship W2138829885A5011671209 @default.
• W2138829885 hasAuthorship W2138829885A5033781594 @default.
• W2138829885 hasAuthorship W2138829885A5048180745 @default.
• W2138829885 hasAuthorship W2138829885A5072910440 @default.
• W2138829885 hasAuthorship W2138829885A5087741712 @default.
• W2138829885 hasBestOaLocation W21388298851 @default.
• W2138829885 hasConcept C104317684 @default.
• W2138829885 hasConcept C137848329 @default.
• W2138829885 hasConcept C144024400 @default.
• W2138829885 hasConcept C149923435 @default.
• W2138829885 hasConcept C180754005 @default.
• W2138829885 hasConcept C207936829 @default.
• W2138829885 hasConcept C2908647359 @default.
• W2138829885 hasConcept C2908694543 @default.
• W2138829885 hasConcept C54355233 @default.
• W2138829885 hasConcept C61320498 @default.
• W2138829885 hasConcept C78458016 @default.
• W2138829885 hasConcept C81977670 @default.
• W2138829885 hasConcept C84597430 @default.
• W2138829885 hasConcept C86803240 @default.
• W2138829885 hasConcept C90856448 @default.
• W2138829885 hasConceptScore W2138829885C104317684 @default.
• W2138829885 hasConceptScore W2138829885C137848329 @default.
• W2138829885 hasConceptScore W2138829885C144024400 @default.
• W2138829885 hasConceptScore W2138829885C149923435 @default.
• W2138829885 hasConceptScore W2138829885C180754005 @default.
• W2138829885 hasConceptScore W2138829885C207936829 @default.
• W2138829885 hasConceptScore W2138829885C2908647359 @default.
• W2138829885 hasConceptScore W2138829885C2908694543 @default.
• W2138829885 hasConceptScore W2138829885C54355233 @default.
• W2138829885 hasConceptScore W2138829885C61320498 @default.
• W2138829885 hasConceptScore W2138829885C78458016 @default.
• W2138829885 hasConceptScore W2138829885C81977670 @default.
• W2138829885 hasConceptScore W2138829885C84597430 @default.
• W2138829885 hasConceptScore W2138829885C86803240 @default.
• W2138829885 hasConceptScore W2138829885C90856448 @default.
• W2138829885 hasIssue "1" @default.

• next