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- W2138830905 abstract "Abstract Acid secretory responses were obtained in rats given either intravenous histamine as dihydrochloride or gastrin subjected to partial purification. A continuous recording method for measuring gastric acid secretion was used. When the rat stomach was perfused with weak sodium hydroxide solution, glycopyrronium bromide (a powerful anticholinergic drug) blocked the acid gastric secretory effects of both histamine and gastrin. Glycopyrronium bromide in doses of 2 μg/100 g body weight of rat is well tolerated. Doses higher than 2 mg/100 g caused respiratory disturbances. The action of glycopyrronium bromide in blocking the gastric secretory effects of gastrin supports the hypothesis that gastrin acts partly by stimulating the vagus nerve." @default.
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- W2138830905 date "1969-08-01" @default.
- W2138830905 modified "2023-10-16" @default.
- W2138830905 title "Effect of glycopyrronium bromide on basal, and histamine- or gastrin-induced gastric secretion" @default.
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- W2138830905 doi "https://doi.org/10.1111/j.2042-7158.1969.tb08301.x" @default.
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