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• W2138832191 abstract "Whether pure thiamine deficiency produces a neuropathy in Mammalia is still debated. Rats were pair-fed-synthetic diets with and without thiamine. When studied histochemically, soleus muscles from thiamine-deficient rats showed (1) small, angular fibers that had high NADH dehydrogenase activities; (2) a loss of 43% of type II (FOG) fibers; (3) decreased intensity of the reaction for betaOHB dehydrogenase; and (4) fibers with subsarcolemmal collections resembling ragged-red muscle. Electron microscopy revealed degeneration of some small myelin sheaths of distal and intramuscular nerves; atrophic, degenerating, hypoosmophilic muscle fibers in soleus and vastus medialis; and scattered muscle fibers with abnormal collections of deranged mitochondria accompanied by lipid droplets. These abnormalities, not found in control muscles, indicate that both motor neuropathy and mild mitochondrial changes, such as are seen in the ragged-red diseases, are induced by pure thiamine deficiency." @default.
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• W2138832191 date "1975-12-01" @default.
• W2138832191 modified "2023-10-17" @default.
• W2138832191 title "Experimental Thiamine Deficiency" @default.
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• W2138832191 doi "https://doi.org/10.1001/archneur.1975.00490540062008" @default.
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