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- W2138835511 abstract "A challenge of synthetic biology is the creation of cooperative microbial systems that exhibit population-level behaviors. Such systems use cellular signaling mechanisms to regulate gene expression across multiple cell types. We describe the construction of a synthetic microbial consortium consisting of two distinct cell types—an activator strain and a repressor strain. These strains produced two orthogonal cell-signaling molecules that regulate gene expression within a synthetic circuit spanning both strains. The two strains generated emergent, population-level oscillations only when cultured together. Certain network topologies of the two-strain circuit were better at maintaining robust oscillations than others. The ability to program population-level dynamics through the genetic engineering of multiple cooperative strains points the way toward engineering complex synthetic tissues and organs with multiple cell types." @default.
- W2138835511 created "2016-06-24" @default.
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- W2138835511 date "2015-08-28" @default.
- W2138835511 modified "2023-10-17" @default.
- W2138835511 title "Emergent genetic oscillations in a synthetic microbial consortium" @default.
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- W2138835511 doi "https://doi.org/10.1126/science.aaa3794" @default.
- W2138835511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4597888" @default.
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