FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138837715> ?p ?o ?g. }

• W2138837715 abstract "In order to improve the presentation and immunogenicity of single epitopes, virus-like particles (VLPs) are being used as platforms for the display of foreing epitopes on their surface. The rotavirus major capsid protein VP6 has the ability to self-assemble into empty non-infectious VLPs. In the present study, we analyzed the use of double layered VLPs (made up of VP2 and VP6 rotavirus proteins) as carriers to display a 14 amino acid epitope fused to three different aminoacidic regions of VP6 exposed on the surface of VLPs. Although all chimeric protein were correctly expressed in insect cells, only one of them resulted in spontaneous assembly of VLPs displaying the heterologous epitope on their surface, confirmed by sandwich ELISA and electron microscopy. Furthermore, the injection of chimeric VLPs into mice elicited higher antibody titers than the monomeric chimeric protein. Our results identify an specific amino acid region of VP6 which allows the insertion of at least a 14 amino acid heterolgous epitope and demonstrate its potential as immunogenic carrier." @default.
• W2138837715 created "2016-06-24" @default.
• W2138837715 creator A5028839300 @default.
• W2138837715 creator A5045836759 @default.
• W2138837715 creator A5052170492 @default.
• W2138837715 date "2009-11-06" @default.
• W2138837715 modified "2023-10-14" @default.
• W2138837715 title "Chimeric recombinant rotavirus-like particles as a vehicle for the display of heterologous epitopes" @default.
• W2138837715 cites W1518848617 @default.
• W2138837715 cites W1567772800 @default.
• W2138837715 cites W1568396084 @default.
• W2138837715 cites W1585061035 @default.
• W2138837715 cites W1970401314 @default.
• W2138837715 cites W1979108986 @default.
• W2138837715 cites W1982830459 @default.
• W2138837715 cites W1984040982 @default.
• W2138837715 cites W1998552130 @default.
• W2138837715 cites W2005522869 @default.
• W2138837715 cites W2010689289 @default.
• W2138837715 cites W2021426402 @default.
• W2138837715 cites W2027433479 @default.
• W2138837715 cites W2034058127 @default.
• W2138837715 cites W2046321439 @default.
• W2138837715 cites W2049095033 @default.
• W2138837715 cites W2053413274 @default.
• W2138837715 cites W2058242300 @default.
• W2138837715 cites W2058675556 @default.
• W2138837715 cites W2075515367 @default.
• W2138837715 cites W2075656541 @default.
• W2138837715 cites W2082329927 @default.
• W2138837715 cites W2083240451 @default.
• W2138837715 cites W2095560925 @default.
• W2138837715 cites W2104280203 @default.
• W2138837715 cites W2115318931 @default.
• W2138837715 cites W2146863397 @default.
• W2138837715 cites W2152959169 @default.
• W2138837715 cites W2162744638 @default.
• W2138837715 cites W2164492975 @default.
• W2138837715 cites W2170592973 @default.
• W2138837715 cites W4254442253 @default.
• W2138837715 cites W73616910 @default.
• W2138837715 doi "https://doi.org/10.1186/1743-422x-6-192" @default.
• W2138837715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2777876" @default.
• W2138837715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19891790" @default.
• W2138837715 hasPublicationYear "2009" @default.
• W2138837715 type Work @default.
• W2138837715 sameAs 2138837715 @default.
• W2138837715 citedByCount "23" @default.
• W2138837715 countsByYear W21388377152012 @default.
• W2138837715 countsByYear W21388377152013 @default.
• W2138837715 countsByYear W21388377152014 @default.
• W2138837715 countsByYear W21388377152015 @default.
• W2138837715 countsByYear W21388377152016 @default.
• W2138837715 countsByYear W21388377152017 @default.
• W2138837715 countsByYear W21388377152019 @default.
• W2138837715 countsByYear W21388377152020 @default.
• W2138837715 countsByYear W21388377152021 @default.
• W2138837715 countsByYear W21388377152022 @default.
• W2138837715 countsByYear W21388377152023 @default.
• W2138837715 crossrefType "journal-article" @default.
• W2138837715 hasAuthorship W2138837715A5028839300 @default.
• W2138837715 hasAuthorship W2138837715A5045836759 @default.
• W2138837715 hasAuthorship W2138837715A5052170492 @default.
• W2138837715 hasBestOaLocation W21388377151 @default.
• W2138837715 hasConcept C104317684 @default.
• W2138837715 hasConcept C123894998 @default.
• W2138837715 hasConcept C153911025 @default.
• W2138837715 hasConcept C159047783 @default.
• W2138837715 hasConcept C159654299 @default.
• W2138837715 hasConcept C195616568 @default.
• W2138837715 hasConcept C202878990 @default.
• W2138837715 hasConcept C2522874641 @default.
• W2138837715 hasConcept C2776387124 @default.
• W2138837715 hasConcept C2780115692 @default.
• W2138837715 hasConcept C2780868878 @default.
• W2138837715 hasConcept C2781367151 @default.
• W2138837715 hasConcept C40767141 @default.
• W2138837715 hasConcept C54355233 @default.
• W2138837715 hasConcept C55493867 @default.
• W2138837715 hasConcept C86803240 @default.
• W2138837715 hasConceptScore W2138837715C104317684 @default.
• W2138837715 hasConceptScore W2138837715C123894998 @default.
• W2138837715 hasConceptScore W2138837715C153911025 @default.
• W2138837715 hasConceptScore W2138837715C159047783 @default.
• W2138837715 hasConceptScore W2138837715C159654299 @default.
• W2138837715 hasConceptScore W2138837715C195616568 @default.
• W2138837715 hasConceptScore W2138837715C202878990 @default.
• W2138837715 hasConceptScore W2138837715C2522874641 @default.
• W2138837715 hasConceptScore W2138837715C2776387124 @default.
• W2138837715 hasConceptScore W2138837715C2780115692 @default.
• W2138837715 hasConceptScore W2138837715C2780868878 @default.
• W2138837715 hasConceptScore W2138837715C2781367151 @default.
• W2138837715 hasConceptScore W2138837715C40767141 @default.
• W2138837715 hasConceptScore W2138837715C54355233 @default.
• W2138837715 hasConceptScore W2138837715C55493867 @default.
• W2138837715 hasConceptScore W2138837715C86803240 @default.
• W2138837715 hasIssue "1" @default.
• W2138837715 hasLocation W21388377151 @default.
• W2138837715 hasLocation W21388377152 @default.
• W2138837715 hasLocation W21388377153 @default.

• next