Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138839504> ?p ?o ?g. }
- W2138839504 endingPage "734" @default.
- W2138839504 startingPage "719" @default.
- W2138839504 abstract "Transplantation of GABAergic interneurons (INs) can provide long-term functional benefits in animal models of epilepsy and other neurological disorders. Whereas GABAergic INs can be differentiated from embryonic stem cells, alternative sources of GABAergic INs may be more tractable for disease modeling and transplantation. We identified five factors (Foxg1, Sox2, Ascl1, Dlx5, and Lhx6) that convert mouse fibroblasts into induced GABAergic INs (iGABA-INs) possessing molecular signatures of telencephalic INs. Factor overexpression activates transcriptional networks required for GABAergic fate specification. iGABA-INs display progressively maturing firing patterns comparable to cortical INs, form functional synapses, and release GABA. Importantly, iGABA-INs survive and mature upon being grafted into mouse hippocampus. Optogenetic stimulation demonstrated functional integration of grafted iGABA-INs into host circuitry, triggering inhibition of host granule neuron activity. These five factors also converted human cells into functional GABAergic INs. These properties suggest that iGABA-INs have potential for disease modeling and cell-based therapeutic approaches to neurological disorders." @default.
- W2138839504 created "2016-06-24" @default.
- W2138839504 creator A5001380417 @default.
- W2138839504 creator A5004567684 @default.
- W2138839504 creator A5015876222 @default.
- W2138839504 creator A5018218680 @default.
- W2138839504 creator A5023104356 @default.
- W2138839504 creator A5029800720 @default.
- W2138839504 creator A5032383705 @default.
- W2138839504 creator A5036477754 @default.
- W2138839504 creator A5049689971 @default.
- W2138839504 creator A5052385937 @default.
- W2138839504 creator A5063116491 @default.
- W2138839504 creator A5066291923 @default.
- W2138839504 creator A5073257998 @default.
- W2138839504 creator A5073562468 @default.
- W2138839504 creator A5073648898 @default.
- W2138839504 creator A5077611338 @default.
- W2138839504 creator A5078152508 @default.
- W2138839504 creator A5083658003 @default.
- W2138839504 creator A5084366630 @default.
- W2138839504 creator A5085465018 @default.
- W2138839504 creator A5089207995 @default.
- W2138839504 date "2015-12-01" @default.
- W2138839504 modified "2023-10-17" @default.
- W2138839504 title "Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming" @default.
- W2138839504 cites W1485442548 @default.
- W2138839504 cites W1539681179 @default.
- W2138839504 cites W1747998245 @default.
- W2138839504 cites W1861019776 @default.
- W2138839504 cites W1963788090 @default.
- W2138839504 cites W1968899084 @default.
- W2138839504 cites W1970644971 @default.
- W2138839504 cites W1986058969 @default.
- W2138839504 cites W1987167495 @default.
- W2138839504 cites W2003835684 @default.
- W2138839504 cites W2009056095 @default.
- W2138839504 cites W2022745333 @default.
- W2138839504 cites W2031842064 @default.
- W2138839504 cites W2033191423 @default.
- W2138839504 cites W2035626925 @default.
- W2138839504 cites W2040027262 @default.
- W2138839504 cites W2048432879 @default.
- W2138839504 cites W2053358049 @default.
- W2138839504 cites W2055421069 @default.
- W2138839504 cites W2057431271 @default.
- W2138839504 cites W2063511140 @default.
- W2138839504 cites W2063883584 @default.
- W2138839504 cites W2072139179 @default.
- W2138839504 cites W2077852611 @default.
- W2138839504 cites W2081581923 @default.
- W2138839504 cites W2088542154 @default.
- W2138839504 cites W2092997802 @default.
- W2138839504 cites W2093314050 @default.
- W2138839504 cites W2095335071 @default.
- W2138839504 cites W2097053397 @default.
- W2138839504 cites W2103131083 @default.
- W2138839504 cites W2117703421 @default.
- W2138839504 cites W2124109473 @default.
- W2138839504 cites W2125842400 @default.
- W2138839504 cites W2135782855 @default.
- W2138839504 cites W2136541538 @default.
- W2138839504 cites W2138921976 @default.
- W2138839504 cites W2144091055 @default.
- W2138839504 cites W2165234851 @default.
- W2138839504 cites W2166364179 @default.
- W2138839504 cites W2166791809 @default.
- W2138839504 doi "https://doi.org/10.1016/j.stem.2015.09.002" @default.
- W2138839504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26526726" @default.
- W2138839504 hasPublicationYear "2015" @default.
- W2138839504 type Work @default.
- W2138839504 sameAs 2138839504 @default.
- W2138839504 citedByCount "135" @default.
- W2138839504 countsByYear W21388395042016 @default.
- W2138839504 countsByYear W21388395042017 @default.
- W2138839504 countsByYear W21388395042018 @default.
- W2138839504 countsByYear W21388395042019 @default.
- W2138839504 countsByYear W21388395042020 @default.
- W2138839504 countsByYear W21388395042021 @default.
- W2138839504 countsByYear W21388395042022 @default.
- W2138839504 countsByYear W21388395042023 @default.
- W2138839504 crossrefType "journal-article" @default.
- W2138839504 hasAuthorship W2138839504A5001380417 @default.
- W2138839504 hasAuthorship W2138839504A5004567684 @default.
- W2138839504 hasAuthorship W2138839504A5015876222 @default.
- W2138839504 hasAuthorship W2138839504A5018218680 @default.
- W2138839504 hasAuthorship W2138839504A5023104356 @default.
- W2138839504 hasAuthorship W2138839504A5029800720 @default.
- W2138839504 hasAuthorship W2138839504A5032383705 @default.
- W2138839504 hasAuthorship W2138839504A5036477754 @default.
- W2138839504 hasAuthorship W2138839504A5049689971 @default.
- W2138839504 hasAuthorship W2138839504A5052385937 @default.
- W2138839504 hasAuthorship W2138839504A5063116491 @default.
- W2138839504 hasAuthorship W2138839504A5066291923 @default.
- W2138839504 hasAuthorship W2138839504A5073257998 @default.
- W2138839504 hasAuthorship W2138839504A5073562468 @default.
- W2138839504 hasAuthorship W2138839504A5073648898 @default.
- W2138839504 hasAuthorship W2138839504A5077611338 @default.