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• W2138840986 abstract "Cortactin is an F-actin binding protein, regulating cell movement and adhesive junction assembly. However, the function of cortactin in epithelial-mesenchymal transition (EMT) remains elusive. Here we found that during transforming growth factor-beta1 (TGF-beta1)- induced EMT in AML-12 murine hepatocytes, cortactin underwent tyrosine dephosphorylation. Inhibition of the dephosphorylation of cortactin by sodium vanadate blocked TGF-beta1-induced EMT. Knockdown of cortactin by RNAi led to decrease of intercellular junction proteins E-cadherin and Zonula occludens-1 and induced expression of mesenchymal protein fibronectin. Additionally, knockdown of cortactin further promoted TGF-beta1-induced EMT in AML-12 cells, as determined by EMT markers and cell morphological changes. Moreover, migration assay showed that cortactin knockdown promoted the migration of AML-12 cells, and also enhanced TGF-beta1-induced migration. Our study showed the involvement of cortactin in the TGFbeta1- induced EMT." @default.
• W2138840986 created "2016-06-24" @default.
• W2138840986 creator A5046356511 @default.
• W2138840986 creator A5053034261 @default.
• W2138840986 creator A5056246750 @default.
• W2138840986 date "2009-10-01" @default.
• W2138840986 modified "2023-10-10" @default.
• W2138840986 title "Cortactin is involved in transforming growth factor-&beta;1-induced epithelial-mesenchymal transition in AML-12 cells" @default.
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• W2138840986 doi "https://doi.org/10.1093/abbs/gmp070" @default.
• W2138840986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19779649" @default.
• W2138840986 hasPublicationYear "2009" @default.
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