Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138845610> ?p ?o ?g. }
- W2138845610 endingPage "391" @default.
- W2138845610 startingPage "381" @default.
- W2138845610 abstract "The Göttingen Minipig (GMP) developed at the University of Göttingen is a synthetic breed that is widely used in medical research and toxicology. It combines the high fertility of the Vietnamese potbellied pig, the low body weight of the Minnesota Minipig and the white coat colour of the German Landrace pig. The aim of this study was to find genomic regions that may have undergone selection since the creation of the breed in the 1960s. Therefore, the whole genome was screened for footprints of recent selection based on single nucleotide polymorphism (SNP) genotypes from the Illumina Porcine SNP60 BeadChip using two methods: the extended haplotype homozygosity (EHH) test and the estimation of the genomic proportion of the three original breeds at each SNP using a Bayesian approach. Local deviations from the average genome-wide breed composition were tested with a permutation-based empirical test. Results for a comprehensive whole-genome scan for both methods are presented. Several regions showing the highest P-values in the EHH test are related to breeding goals relevant in the GMP, such as growth (SOCS2, TXN, DDR2 and GRB10 genes) and white colour (PRLR gene). Additionally, the calculated proportion of the founder breeds diverged significantly in many regions from the pedigree-based expectations and the genome average. The results provide a genome-wide map of selection signatures in the GMP, which leads to a better understanding of selection that took place over the last decades in GMP breed development." @default.
- W2138845610 created "2016-06-24" @default.
- W2138845610 creator A5020297143 @default.
- W2138845610 creator A5028346081 @default.
- W2138845610 creator A5058285950 @default.
- W2138845610 creator A5062358993 @default.
- W2138845610 creator A5082768576 @default.
- W2138845610 creator A5087242393 @default.
- W2138845610 date "2014-03-29" @default.
- W2138845610 modified "2023-09-27" @default.
- W2138845610 title "Footprints of recent selection and variability in breed composition in the Göttingen Minipig genome" @default.
- W2138845610 cites W158079064 @default.
- W2138845610 cites W1600880434 @default.
- W2138845610 cites W1971566284 @default.
- W2138845610 cites W2001177530 @default.
- W2138845610 cites W2003459694 @default.
- W2138845610 cites W2006712471 @default.
- W2138845610 cites W2013197522 @default.
- W2138845610 cites W2023391610 @default.
- W2138845610 cites W2027768994 @default.
- W2138845610 cites W2028084460 @default.
- W2138845610 cites W2029723752 @default.
- W2138845610 cites W2032570331 @default.
- W2138845610 cites W2033995133 @default.
- W2138845610 cites W2040660061 @default.
- W2138845610 cites W2055543630 @default.
- W2138845610 cites W2058276650 @default.
- W2138845610 cites W2061276185 @default.
- W2138845610 cites W2069944921 @default.
- W2138845610 cites W2093517093 @default.
- W2138845610 cites W2097325658 @default.
- W2138845610 cites W2107958457 @default.
- W2138845610 cites W2111352469 @default.
- W2138845610 cites W2115837368 @default.
- W2138845610 cites W2116668053 @default.
- W2138845610 cites W2118055782 @default.
- W2138845610 cites W2118941667 @default.
- W2138845610 cites W2121853900 @default.
- W2138845610 cites W2135370544 @default.
- W2138845610 cites W2138480739 @default.
- W2138845610 cites W2142851097 @default.
- W2138845610 cites W2148589694 @default.
- W2138845610 cites W2150675449 @default.
- W2138845610 cites W2152664025 @default.
- W2138845610 cites W2153607816 @default.
- W2138845610 cites W2161218253 @default.
- W2138845610 cites W4247623413 @default.
- W2138845610 cites W4251304755 @default.
- W2138845610 doi "https://doi.org/10.1111/age.12150" @default.
- W2138845610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24684393" @default.
- W2138845610 hasPublicationYear "2014" @default.
- W2138845610 type Work @default.
- W2138845610 sameAs 2138845610 @default.
- W2138845610 citedByCount "8" @default.
- W2138845610 countsByYear W21388456102014 @default.
- W2138845610 countsByYear W21388456102016 @default.
- W2138845610 countsByYear W21388456102018 @default.
- W2138845610 countsByYear W21388456102020 @default.
- W2138845610 crossrefType "journal-article" @default.
- W2138845610 hasAuthorship W2138845610A5020297143 @default.
- W2138845610 hasAuthorship W2138845610A5028346081 @default.
- W2138845610 hasAuthorship W2138845610A5058285950 @default.
- W2138845610 hasAuthorship W2138845610A5062358993 @default.
- W2138845610 hasAuthorship W2138845610A5082768576 @default.
- W2138845610 hasAuthorship W2138845610A5087242393 @default.
- W2138845610 hasConcept C104317684 @default.
- W2138845610 hasConcept C135763542 @default.
- W2138845610 hasConcept C139275648 @default.
- W2138845610 hasConcept C141231307 @default.
- W2138845610 hasConcept C153209595 @default.
- W2138845610 hasConcept C154945302 @default.
- W2138845610 hasConcept C2776482104 @default.
- W2138845610 hasConcept C2992444039 @default.
- W2138845610 hasConcept C41008148 @default.
- W2138845610 hasConcept C54355233 @default.
- W2138845610 hasConcept C81917197 @default.
- W2138845610 hasConcept C86803240 @default.
- W2138845610 hasConceptScore W2138845610C104317684 @default.
- W2138845610 hasConceptScore W2138845610C135763542 @default.
- W2138845610 hasConceptScore W2138845610C139275648 @default.
- W2138845610 hasConceptScore W2138845610C141231307 @default.
- W2138845610 hasConceptScore W2138845610C153209595 @default.
- W2138845610 hasConceptScore W2138845610C154945302 @default.
- W2138845610 hasConceptScore W2138845610C2776482104 @default.
- W2138845610 hasConceptScore W2138845610C2992444039 @default.
- W2138845610 hasConceptScore W2138845610C41008148 @default.
- W2138845610 hasConceptScore W2138845610C54355233 @default.
- W2138845610 hasConceptScore W2138845610C81917197 @default.
- W2138845610 hasConceptScore W2138845610C86803240 @default.
- W2138845610 hasIssue "3" @default.
- W2138845610 hasLocation W21388456101 @default.
- W2138845610 hasLocation W21388456102 @default.
- W2138845610 hasOpenAccess W2138845610 @default.
- W2138845610 hasPrimaryLocation W21388456101 @default.
- W2138845610 hasRelatedWork W1517693310 @default.
- W2138845610 hasRelatedWork W1979012797 @default.
- W2138845610 hasRelatedWork W1984103522 @default.
- W2138845610 hasRelatedWork W2075926380 @default.