FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138849500> ?p ?o ?g. }

• W2138849500 endingPage "H3731" @default.
• W2138849500 startingPage "H3726" @default.
• W2138849500 abstract "Endotoxin [or lipopolysaccharide (LPS)] increases levels of superoxide in blood vessels and impairs vasomotor function. Angiotensin II plays an important role in the generation of superoxide in several disease states, including hypertension and heart failure. The goal of this study was to determine whether the activation of the renin-angiotensin system contributes to oxidative stress and endothelial dysfunction after endotoxin. We examined the effects of enalapril (an angiotensin-converting enzyme inhibitor) or L-158809 (an angiotensin receptor blocker) on increases of superoxide and vasomotor dysfunction in mice treated with LPS. C57BL/6 mice were treated with either enalapril (60 mg.kg(-1).day(-1)) or L-158809 (30 mg.kg(-1).day(-1)) for 4 days. After the third day, LPS (10-20 mg/kg) or vehicle was injected intraperitoneally, and one day later, vasomotor function of the aorta was examined in vitro. After precontraction with PGF(2alpha), the maximal responses to sodium nitroprusside were similar in the aorta from normal and LPS-treated mice. In contrast, the relaxation to acetylcholine was impaired after LPS (54 +/- 5% at 10(-5), mean +/- SE) compared with vessels treated with vehicle (88 +/- 1%; P < 0.05). Enalapril improved (P < 0.05) relaxation in response to acetylcholine to 81 +/- 6% after LPS. L-158809 also improved relaxation in response to acetylcholine to 77 +/- 4% after LPS. Superoxide (measured with lucigenin and hydroethidine) was increased (P < 0.05) in aorta after LPS, and levels were reduced (P < 0.05) following enalapril and L-158809. Thus, after LPS, enalapril and L-158809 reduce superoxide levels and improve relaxation to acetylcholine in the aorta. The findings suggest that activation of the renin-angiotensin system contributes importantly to oxidative stress and endothelial dysfunction after endotoxin." @default.
• W2138849500 created "2016-06-24" @default.
• W2138849500 creator A5021087036 @default.
• W2138849500 creator A5052680663 @default.
• W2138849500 creator A5077989922 @default.
• W2138849500 creator A5091500935 @default.
• W2138849500 date "2007-12-01" @default.
• W2138849500 modified "2023-09-30" @default.
• W2138849500 title "Role of angiotensin II in endothelial dysfunction induced by lipopolysaccharide in mice" @default.
• W2138849500 cites W1533750424 @default.
• W2138849500 cites W1767113463 @default.
• W2138849500 cites W1877899417 @default.
• W2138849500 cites W1976555160 @default.
• W2138849500 cites W1977597520 @default.
• W2138849500 cites W1980715790 @default.
• W2138849500 cites W1988500109 @default.
• W2138849500 cites W1991306589 @default.
• W2138849500 cites W2000161513 @default.
• W2138849500 cites W2010242599 @default.
• W2138849500 cites W2010458924 @default.
• W2138849500 cites W2012142430 @default.
• W2138849500 cites W2014854748 @default.
• W2138849500 cites W2015997429 @default.
• W2138849500 cites W2043058882 @default.
• W2138849500 cites W2043628281 @default.
• W2138849500 cites W2054190158 @default.
• W2138849500 cites W2056716295 @default.
• W2138849500 cites W2070641536 @default.
• W2138849500 cites W2071695884 @default.
• W2138849500 cites W2074957886 @default.
• W2138849500 cites W2075181947 @default.
• W2138849500 cites W2081398865 @default.
• W2138849500 cites W2081605468 @default.
• W2138849500 cites W2089561842 @default.
• W2138849500 cites W2096655296 @default.
• W2138849500 cites W2104733318 @default.
• W2138849500 cites W2109137627 @default.
• W2138849500 cites W2123799914 @default.
• W2138849500 cites W2126698280 @default.
• W2138849500 cites W2133150758 @default.
• W2138849500 cites W2137737171 @default.
• W2138849500 cites W2139551405 @default.
• W2138849500 cites W2144798177 @default.
• W2138849500 cites W2148637873 @default.
• W2138849500 cites W2158796764 @default.
• W2138849500 cites W2167866149 @default.
• W2138849500 cites W2208872067 @default.
• W2138849500 doi "https://doi.org/10.1152/ajpheart.01116.2007" @default.
• W2138849500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17965276" @default.
• W2138849500 hasPublicationYear "2007" @default.
• W2138849500 type Work @default.
• W2138849500 sameAs 2138849500 @default.
• W2138849500 citedByCount "41" @default.
• W2138849500 countsByYear W21388495002013 @default.
• W2138849500 countsByYear W21388495002014 @default.
• W2138849500 countsByYear W21388495002015 @default.
• W2138849500 countsByYear W21388495002016 @default.
• W2138849500 countsByYear W21388495002017 @default.
• W2138849500 countsByYear W21388495002018 @default.
• W2138849500 countsByYear W21388495002019 @default.
• W2138849500 countsByYear W21388495002020 @default.
• W2138849500 countsByYear W21388495002021 @default.
• W2138849500 countsByYear W21388495002022 @default.
• W2138849500 countsByYear W21388495002023 @default.
• W2138849500 crossrefType "journal-article" @default.
• W2138849500 hasAuthorship W2138849500A5021087036 @default.
• W2138849500 hasAuthorship W2138849500A5052680663 @default.
• W2138849500 hasAuthorship W2138849500A5077989922 @default.
• W2138849500 hasAuthorship W2138849500A5091500935 @default.
• W2138849500 hasConcept C126322002 @default.
• W2138849500 hasConcept C134018914 @default.
• W2138849500 hasConcept C170493617 @default.
• W2138849500 hasConcept C181199279 @default.
• W2138849500 hasConcept C185592680 @default.
• W2138849500 hasConcept C198710026 @default.
• W2138849500 hasConcept C24998067 @default.
• W2138849500 hasConcept C27016395 @default.
• W2138849500 hasConcept C2775910092 @default.
• W2138849500 hasConcept C2775940317 @default.
• W2138849500 hasConcept C2776090920 @default.
• W2138849500 hasConcept C2776214587 @default.
• W2138849500 hasConcept C2776992346 @default.
• W2138849500 hasConcept C2779610285 @default.
• W2138849500 hasConcept C2780795997 @default.
• W2138849500 hasConcept C2780972559 @default.
• W2138849500 hasConcept C2908929049 @default.
• W2138849500 hasConcept C519581460 @default.
• W2138849500 hasConcept C55493867 @default.
• W2138849500 hasConcept C71924100 @default.
• W2138849500 hasConcept C84393581 @default.
• W2138849500 hasConceptScore W2138849500C126322002 @default.
• W2138849500 hasConceptScore W2138849500C134018914 @default.
• W2138849500 hasConceptScore W2138849500C170493617 @default.
• W2138849500 hasConceptScore W2138849500C181199279 @default.
• W2138849500 hasConceptScore W2138849500C185592680 @default.
• W2138849500 hasConceptScore W2138849500C198710026 @default.
• W2138849500 hasConceptScore W2138849500C24998067 @default.
• W2138849500 hasConceptScore W2138849500C27016395 @default.

• next