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- W2138855178 abstract "SUMMARY The antibiotic resistance of Mycoplasma mycoides ssp. mycoides strain T 1 was investigated. This strain was resistant to high levels ( > 100 μg ml −1 ) of rifampicin and nalidixic acid. It was sensitive to streptomycin, spectinomycin and novobiocin; however, single step mutants with high levels of resistance ( > 100 μg ml −1 ) were readily isolated. With erythromycin and tylosin for which the minimum inhibitory concentration (MIC) for the parent strain was < 0·1 μg ml −1 , mutants resistant to > 100 μg ml −1 were obtained in two and three steps respectively. The MIC of tetracycline in single step resistant mutants (0·6 μg ml −1 ) was tenfold higher than the parent strain, but could not be increased further. There was only a twofold increase in resistance to chloramphenicol in single step mutants. The frequency of resistant mutants varied with the antibiotic and was between 4× 10 minuss;6 and 2× 10 −8 . The mutation rate to antibiotic resistance to streptomycin, spectinomycin, novobiocin, erythromycin and tylosin was between 3× 10 −8 and 5× 10 −9 per cell per generation. There was a fivefold decrease in mutation rate to resistance to 60 μg ml −1 streptomycin compared to that to 20 μg ml −1 ." @default.
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- W2138855178 date "1987-06-01" @default.
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- W2138855178 title "Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides" @default.
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- W2138855178 doi "https://doi.org/10.1017/s0950268800062129" @default.
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