FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138860997> ?p ?o ?g. }

• W2138860997 endingPage "260" @default.
• W2138860997 startingPage "254" @default.
• W2138860997 abstract "Hypertrophic cardiomyopathy (HCM) is a genetic disorder of cardiac muscle with a prevalence of 1 in 500 of the general population.w1 In most adults, HCM is inherited as an autosomal dominant trait caused by mutations in genes encoding cardiac sarcomere proteins.1 The disease is clinically defined by left ventricular hypertrophy (LVH) unexplained by abnormal loading conditions,2 and is often associated with left ventricular outflow tract obstruction (LVOTO) caused by the systolic anterior movement of the mitral valve.w2 Histologically, HCM is characterised by cardiomyocyte hypertrophy and disarray, myocardial fibrosis, and small vessel disease.1 w3Sudden cardiac death (SCD), heart failure, and thromboembolism are the main causes of death.3 Early studies of small HCM cohorts from tertiary referral centres reported cardiovascular mortality rates of ∼6%/year, but later less selected studies demonstrated a more favourable clinical course with an overall cardiovascular mortality of ∼2%/year.3 Nevertheless, SCD still occurs with an incidence of ∼0.8%/year, peaking in early adulthood.4 ,5 As observational data suggest that implantable cardioverter defibrillators (ICDs) can prevent SCD, there is a clinical need to identify accurately individual patients at high risk.Numerous cardiac arrhythmias have been reported in association with SCD in HCM, including asystole,w4 atrioventricular block,w5 pulseless electrical activity,w6 w7 and supraventricular arrhythmias.w8 Data from chance electrocardiographic recordings and stored intracardiac electrograms from ICDs suggest that SCD in HCM is most commonly caused by ventricular fibrillation (VF).w9 w10 The characteristic cellular disarray and cardiac hypertrophy facilitate the development of re-entry arrhythmias,w11 and delayed after depolarisations caused by calcium (Ca2+) leak from the sarcoplasmic reticulum render the myocardium vulnerable to triggered activity.w12 Increased myofilament Ca2+ sensitivity also causes shorter effective refractory periods and increased dispersion of repolarisation, predisposing to functional re-entry.w13Despite …" @default.
• W2138860997 created "2016-06-24" @default.
• W2138860997 creator A5006211041 @default.
• W2138860997 creator A5044767437 @default.
• W2138860997 date "2013-04-10" @default.
• W2138860997 modified "2023-10-06" @default.
• W2138860997 title "Prevention of sudden cardiac death in hypertrophic cardiomyopathy" @default.
• W2138860997 cites W1965849691 @default.
• W2138860997 cites W1966107560 @default.
• W2138860997 cites W1996636073 @default.
• W2138860997 cites W2042390800 @default.
• W2138860997 cites W2068698281 @default.
• W2138860997 cites W2070320179 @default.
• W2138860997 cites W2103423712 @default.
• W2138860997 cites W2107752854 @default.
• W2138860997 cites W2113437018 @default.
• W2138860997 cites W2118891131 @default.
• W2138860997 cites W2118933677 @default.
• W2138860997 cites W2120813609 @default.
• W2138860997 cites W2128788602 @default.
• W2138860997 cites W2135302420 @default.
• W2138860997 cites W2144956569 @default.
• W2138860997 cites W2151730996 @default.
• W2138860997 cites W2156505087 @default.
• W2138860997 cites W2556064842 @default.
• W2138860997 cites W3186521396 @default.
• W2138860997 cites W4211091077 @default.
• W2138860997 doi "https://doi.org/10.1136/heartjnl-2012-301996" @default.
• W2138860997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23574968" @default.
• W2138860997 hasPublicationYear "2013" @default.
• W2138860997 type Work @default.
• W2138860997 sameAs 2138860997 @default.
• W2138860997 citedByCount "29" @default.
• W2138860997 countsByYear W21388609972014 @default.
• W2138860997 countsByYear W21388609972015 @default.
• W2138860997 countsByYear W21388609972016 @default.
• W2138860997 countsByYear W21388609972017 @default.
• W2138860997 countsByYear W21388609972018 @default.
• W2138860997 countsByYear W21388609972020 @default.
• W2138860997 countsByYear W21388609972021 @default.
• W2138860997 countsByYear W21388609972022 @default.
• W2138860997 countsByYear W21388609972023 @default.
• W2138860997 crossrefType "journal-article" @default.
• W2138860997 hasAuthorship W2138860997A5006211041 @default.
• W2138860997 hasAuthorship W2138860997A5044767437 @default.
• W2138860997 hasBestOaLocation W21388609971 @default.
• W2138860997 hasConcept C126322002 @default.
• W2138860997 hasConcept C164705383 @default.
• W2138860997 hasConcept C2775935837 @default.
• W2138860997 hasConcept C2778198053 @default.
• W2138860997 hasConcept C2778797674 @default.
• W2138860997 hasConcept C2780185194 @default.
• W2138860997 hasConcept C2993353509 @default.
• W2138860997 hasConcept C71924100 @default.
• W2138860997 hasConceptScore W2138860997C126322002 @default.
• W2138860997 hasConceptScore W2138860997C164705383 @default.
• W2138860997 hasConceptScore W2138860997C2775935837 @default.
• W2138860997 hasConceptScore W2138860997C2778198053 @default.
• W2138860997 hasConceptScore W2138860997C2778797674 @default.
• W2138860997 hasConceptScore W2138860997C2780185194 @default.
• W2138860997 hasConceptScore W2138860997C2993353509 @default.
• W2138860997 hasConceptScore W2138860997C71924100 @default.
• W2138860997 hasIssue "3" @default.
• W2138860997 hasLocation W21388609971 @default.
• W2138860997 hasLocation W21388609972 @default.
• W2138860997 hasOpenAccess W2138860997 @default.
• W2138860997 hasPrimaryLocation W21388609971 @default.
• W2138860997 hasRelatedWork W1531601525 @default.
• W2138860997 hasRelatedWork W2067800680 @default.
• W2138860997 hasRelatedWork W2758277628 @default.
• W2138860997 hasRelatedWork W2935909890 @default.
• W2138860997 hasRelatedWork W2948807893 @default.
• W2138860997 hasRelatedWork W3025302051 @default.
• W2138860997 hasRelatedWork W3173606202 @default.
• W2138860997 hasRelatedWork W3183948672 @default.
• W2138860997 hasRelatedWork W2778153218 @default.
• W2138860997 hasRelatedWork W3110381201 @default.
• W2138860997 hasVolume "100" @default.
• W2138860997 isParatext "false" @default.
• W2138860997 isRetracted "false" @default.
• W2138860997 magId "2138860997" @default.
• W2138860997 workType "article" @default.