Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138861048> ?p ?o ?g. }
- W2138861048 endingPage "486" @default.
- W2138861048 startingPage "473" @default.
- W2138861048 abstract "Cardiac hypertrophy is one of the main ways in which cardiomyocytes respond to mechanical and neurohormonal stimuli. It enables myocytes to increase their work output, which improves cardiac pump function. However, this compensatory mechanism can become overwhelmed by biomechanical stress, thereby resulting in heart failure, which is associated with high morbidity and mortality. The complex molecular processes that lead to cardiomyocyte growth involve membrane receptors, second messengers, and transcription factors. The common final pathway of all these intracellular substances is gene expression, whose variations are being revealed in increasing detail. The genetic response is characterized by the re-expression of fetal genes, an event which is regarded as the molecular marker of pathologic cardiac hypertrophy, and which is absent in normal physiologic cardiac growth. The possibility of stopping or reversing pathologic cardiac hypertrophy and, thereby, slowing the development of heart failure is a topic of considerable clinical interest and a large amount of relevant data has accumulated. The purpose of this review was to provide a schematic overview of current knowledge about the molecular pathogenesis of cardiomyocyte hypertrophy, with special emphasis on new research topics and investigations." @default.
- W2138861048 created "2016-06-24" @default.
- W2138861048 creator A5022223870 @default.
- W2138861048 creator A5037121206 @default.
- W2138861048 creator A5072196571 @default.
- W2138861048 creator A5080464133 @default.
- W2138861048 date "2006-05-01" @default.
- W2138861048 modified "2023-10-16" @default.
- W2138861048 title "Cardiac Hypertrophy: Molecular and Cellular Events" @default.
- W2138861048 cites W1479831323 @default.
- W2138861048 cites W1526810355 @default.
- W2138861048 cites W1534224609 @default.
- W2138861048 cites W1577378394 @default.
- W2138861048 cites W1588725890 @default.
- W2138861048 cites W1889002087 @default.
- W2138861048 cites W1964472431 @default.
- W2138861048 cites W1965646486 @default.
- W2138861048 cites W1966485417 @default.
- W2138861048 cites W1966534958 @default.
- W2138861048 cites W1967364632 @default.
- W2138861048 cites W1968547385 @default.
- W2138861048 cites W1969052554 @default.
- W2138861048 cites W1970466959 @default.
- W2138861048 cites W1973386259 @default.
- W2138861048 cites W1974159422 @default.
- W2138861048 cites W1974942480 @default.
- W2138861048 cites W1976791051 @default.
- W2138861048 cites W1978162225 @default.
- W2138861048 cites W1980322984 @default.
- W2138861048 cites W1985076614 @default.
- W2138861048 cites W1985130075 @default.
- W2138861048 cites W1985233117 @default.
- W2138861048 cites W1988465147 @default.
- W2138861048 cites W1988563456 @default.
- W2138861048 cites W1991811857 @default.
- W2138861048 cites W1995380251 @default.
- W2138861048 cites W1997340166 @default.
- W2138861048 cites W1998860371 @default.
- W2138861048 cites W2005471059 @default.
- W2138861048 cites W2008434058 @default.
- W2138861048 cites W2016193552 @default.
- W2138861048 cites W2019831571 @default.
- W2138861048 cites W2020672093 @default.
- W2138861048 cites W2021860877 @default.
- W2138861048 cites W2022185139 @default.
- W2138861048 cites W2023687572 @default.
- W2138861048 cites W2024050471 @default.
- W2138861048 cites W2024782147 @default.
- W2138861048 cites W2026472826 @default.
- W2138861048 cites W2028761750 @default.
- W2138861048 cites W2041043528 @default.
- W2138861048 cites W2044443940 @default.
- W2138861048 cites W2045892052 @default.
- W2138861048 cites W2046414016 @default.
- W2138861048 cites W2047373489 @default.
- W2138861048 cites W2047388011 @default.
- W2138861048 cites W2047503478 @default.
- W2138861048 cites W2048047704 @default.
- W2138861048 cites W2049182869 @default.
- W2138861048 cites W2050182552 @default.
- W2138861048 cites W2050822891 @default.
- W2138861048 cites W2052788413 @default.
- W2138861048 cites W2054727930 @default.
- W2138861048 cites W2056311227 @default.
- W2138861048 cites W2056539292 @default.
- W2138861048 cites W2056982291 @default.
- W2138861048 cites W2058465745 @default.
- W2138861048 cites W2060300790 @default.
- W2138861048 cites W2063959543 @default.
- W2138861048 cites W2066987802 @default.
- W2138861048 cites W2067601335 @default.
- W2138861048 cites W2067837318 @default.
- W2138861048 cites W2068432651 @default.
- W2138861048 cites W2068482643 @default.
- W2138861048 cites W2068766125 @default.
- W2138861048 cites W2073084507 @default.
- W2138861048 cites W2073536649 @default.
- W2138861048 cites W2075858413 @default.
- W2138861048 cites W2078057735 @default.
- W2138861048 cites W2079006323 @default.
- W2138861048 cites W2086392932 @default.
- W2138861048 cites W2087133841 @default.
- W2138861048 cites W2088058903 @default.
- W2138861048 cites W2089007506 @default.
- W2138861048 cites W2090663991 @default.
- W2138861048 cites W2092685208 @default.
- W2138861048 cites W2094138142 @default.
- W2138861048 cites W2094806874 @default.
- W2138861048 cites W2096628719 @default.
- W2138861048 cites W2098412336 @default.
- W2138861048 cites W2099093659 @default.
- W2138861048 cites W2103188230 @default.
- W2138861048 cites W2106900373 @default.
- W2138861048 cites W2107590406 @default.
- W2138861048 cites W2108555523 @default.
- W2138861048 cites W2108576156 @default.
- W2138861048 cites W2109170723 @default.
- W2138861048 cites W2110443482 @default.