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- W2138863798 abstract "Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial carriers. Here, we highlight recent findings regarding UCP2 function in the immune system. UCP2 controls immune cell activation by modulating MAPK pathways and the production of mitochondrial reactive oxygen species. In several models of infection, inflammation and autoimmunity, a regulatory impact of UCP2 was demonstrated by its direct implication in the production of cytokines and nitric oxide and in cell migration. In addition, UCP2 is reported as a key protein for oxidation of fatty acids, glutamine and glucose. Therefore we present a model of how the regulation of nutrient oxidation by UCP2 promotes immune cell activation." @default.
- W2138863798 created "2016-06-24" @default.
- W2138863798 creator A5003422112 @default.
- W2138863798 creator A5055102068 @default.
- W2138863798 date "2010-03-12" @default.
- W2138863798 modified "2023-10-02" @default.
- W2138863798 title "Uncoupling protein UCP2: When mitochondrial activity meets immunity" @default.
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- W2138863798 doi "https://doi.org/10.1016/j.febslet.2010.03.014" @default.
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