FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138894342> ?p ?o ?g. }

• W2138894342 endingPage "928" @default.
• W2138894342 startingPage "915" @default.
• W2138894342 abstract "The differentiation and morphogenesis of neural tissues involves a diversity of interactions between neural cells and their environment. Many potentially important interactions occur with the extracellular matrix (ECM), a complex association of extracellular glycoproteins organized into aggregates and polymers. In this article, we discuss recent findings on neuronal interactions with the ECM and their roles in neural cell migration and neurite growth. First, we examine the expression and putative functions of the molecules of the neural ECM. Second, we discuss cell surface molecules that mediate neural interactions with ECM components. Last, we address proteoglycans (PGs), a diverse class of glycoproteins, present both as ECM components and as cell surface molecules, which may mediate neural interactions with their environment. The best-understood cellular interactions with the ECM are adhesive, mediated by binding between specific cell surface molecules and cell binding domains of ECM components (Strittmater and Fishman, 199 1; Damsky and Werb, 1992). Cellsubstratum adhesion is necessary for major cell movements of neuron morphogenesis, that is, the migrations of neural cells and their precursors and the migratory behavior ofgrowth cones at the extending tips of axons and dendrites. As cells move, adhesive molecules at the surface of the leading edge of a migrating cell or growth cone bind to ligands on other cell surfaces or ECM components. These bonds stabilize filopodia and lamellipodia, and, in some cases, provide anchorage against which cytoskeletal filaments, associated with the plasma membrane, exert forces to pull the cell or growth cone forward. Thus, ECM has been primarily viewed as an adhesive substratum to provide traction for migrating cells and to stabilize the position and, perhaps, the state of differentiation of nonmotile cells. However, the interactions between neural cells and the ECM are not longer regarded as only adhesive or mechanical. Two points are now clear. First, some of these interactions are definitely not adhesive, but, rather, they may even be antiadhesive (Chiquet-Ehrismann, 199 1). Second, evidence has accumulated to indicate that the cell surface molecules that mediate cell-cell and cell-ECM interactions (immunoglobulin superfamily, cad" @default.
• W2138894342 created "2016-06-24" @default.
• W2138894342 creator A5052026745 @default.
• W2138894342 creator A5058111972 @default.
• W2138894342 creator A5087495220 @default.
• W2138894342 date "1994-03-01" @default.
• W2138894342 modified "2023-10-02" @default.
• W2138894342 title "Interactions of developing neurons with the extracellular matrix" @default.
• W2138894342 cites W1483788243 @default.
• W2138894342 cites W1484827186 @default.
• W2138894342 cites W1496627300 @default.
• W2138894342 cites W1501588760 @default.
• W2138894342 cites W1502618437 @default.
• W2138894342 cites W1531779321 @default.
• W2138894342 cites W1559464451 @default.
• W2138894342 cites W1561354622 @default.
• W2138894342 cites W1574987094 @default.
• W2138894342 cites W1579361735 @default.
• W2138894342 cites W1588115842 @default.
• W2138894342 cites W1590156932 @default.
• W2138894342 cites W1598171890 @default.
• W2138894342 cites W1605261416 @default.
• W2138894342 cites W1805790794 @default.
• W2138894342 cites W1866676984 @default.
• W2138894342 cites W1879100080 @default.
• W2138894342 cites W1882780242 @default.
• W2138894342 cites W1884786349 @default.
• W2138894342 cites W189154610 @default.
• W2138894342 cites W1905081238 @default.
• W2138894342 cites W1928800192 @default.
• W2138894342 cites W1931621770 @default.
• W2138894342 cites W1936798553 @default.
• W2138894342 cites W1937759229 @default.
• W2138894342 cites W1949509566 @default.
• W2138894342 cites W1950519844 @default.
• W2138894342 cites W1964834956 @default.
• W2138894342 cites W1966087966 @default.
• W2138894342 cites W1966272997 @default.
• W2138894342 cites W1967051516 @default.
• W2138894342 cites W1967722867 @default.
• W2138894342 cites W1968327773 @default.
• W2138894342 cites W1968989887 @default.
• W2138894342 cites W1969846643 @default.
• W2138894342 cites W1970656914 @default.
• W2138894342 cites W1970680825 @default.
• W2138894342 cites W1971266269 @default.
• W2138894342 cites W1972188808 @default.
• W2138894342 cites W1973238216 @default.
• W2138894342 cites W1973339181 @default.
• W2138894342 cites W1974477641 @default.
• W2138894342 cites W1974873948 @default.
• W2138894342 cites W1975741118 @default.
• W2138894342 cites W1977781293 @default.
• W2138894342 cites W1979505297 @default.
• W2138894342 cites W1979993280 @default.
• W2138894342 cites W1982502750 @default.
• W2138894342 cites W1983212899 @default.
• W2138894342 cites W1984000489 @default.
• W2138894342 cites W1985702485 @default.
• W2138894342 cites W1987002949 @default.
• W2138894342 cites W1987939568 @default.
• W2138894342 cites W1989586262 @default.
• W2138894342 cites W1991131108 @default.
• W2138894342 cites W1998031852 @default.
• W2138894342 cites W1999033595 @default.
• W2138894342 cites W1999623969 @default.
• W2138894342 cites W2000265611 @default.
• W2138894342 cites W2001142871 @default.
• W2138894342 cites W2003321237 @default.
• W2138894342 cites W2003782406 @default.
• W2138894342 cites W2003796440 @default.
• W2138894342 cites W2006275687 @default.
• W2138894342 cites W2006565235 @default.
• W2138894342 cites W2008316468 @default.
• W2138894342 cites W2010265636 @default.
• W2138894342 cites W2010295320 @default.
• W2138894342 cites W2010859284 @default.
• W2138894342 cites W2012053447 @default.
• W2138894342 cites W2012447063 @default.
• W2138894342 cites W2013251855 @default.
• W2138894342 cites W2013683218 @default.
• W2138894342 cites W2013727178 @default.
• W2138894342 cites W2014678714 @default.
• W2138894342 cites W2014796360 @default.
• W2138894342 cites W2015096068 @default.
• W2138894342 cites W2015422306 @default.
• W2138894342 cites W2017221392 @default.
• W2138894342 cites W2018396790 @default.
• W2138894342 cites W2018938193 @default.
• W2138894342 cites W2021346586 @default.
• W2138894342 cites W2022010819 @default.
• W2138894342 cites W2022784446 @default.
• W2138894342 cites W2023069127 @default.
• W2138894342 cites W2023153142 @default.
• W2138894342 cites W2024019011 @default.
• W2138894342 cites W2024102606 @default.
• W2138894342 cites W2024492106 @default.
• W2138894342 cites W2027126363 @default.

• next