FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138897907> ?p ?o ?g. }

• W2138897907 endingPage "2343" @default.
• W2138897907 startingPage "2332" @default.
• W2138897907 abstract "Advanced glycation end products (AGEs) accumulate during aging and to higher extents under pathological conditions such as diabetes. Since we previously showed that mast cells expressed the AGE-binding protein, receptor for AGEs (RAGE) on their cell surface, we examined whether AGE affected mast cell survival. Herein, we demonstrate that mast cells undergo apoptosis in response to AGE. Glycated albumin (GA), an AGE, but not stimulation with the high-affinity IgE receptor (FcɛRI), can induce mast cell death, as measured by annexin V/propidium iodide double-staining. GA (≥ 0.1 mg/ml) exhibited this pro-apoptotic activity in a concentration-dependent manner. GA and FcɛRI stimulation increased the cytosolic Ca 2+ levels to a similar extent, whereas GA, but not FcɛRI stimulation, caused mitochondrial Ca 2+ overload and membrane potential collapse, resulting in mitochondrial integrity disruption, cytochrome c release and caspase-3/7 activation. In addition, GA, but not FcɛRI stimulation, induced extracellular release of superoxide from mitochondria, and this release played a key role in the disruption of Ca 2+ homeostasis. Knockdown of RAGE expression using small interfering RNA abolished GA-induced apoptosis, mitochondrial Ca 2+ overload, and superoxide release, demonstrating that RAGE mediates the GA-induced mitochondrial death pathway. AGE-induced mast cell apoptosis may contribute to the immunocompromised and inflammatory conditions." @default.
• W2138897907 created "2016-06-24" @default.
• W2138897907 creator A5001389064 @default.
• W2138897907 creator A5007909935 @default.
• W2138897907 creator A5022840246 @default.
• W2138897907 creator A5031542615 @default.
• W2138897907 creator A5068179878 @default.
• W2138897907 date "2008-12-01" @default.
• W2138897907 modified "2023-09-29" @default.
• W2138897907 title "Extracellular superoxide released from mitochondria mediates mast cell death by advanced glycation end products" @default.
• W2138897907 cites W1503258737 @default.
• W2138897907 cites W1532082751 @default.
• W2138897907 cites W1557253076 @default.
• W2138897907 cites W1971065236 @default.
• W2138897907 cites W1986585141 @default.
• W2138897907 cites W1990773395 @default.
• W2138897907 cites W1993131507 @default.
• W2138897907 cites W1994731621 @default.
• W2138897907 cites W1996602412 @default.
• W2138897907 cites W2001014014 @default.
• W2138897907 cites W2005653939 @default.
• W2138897907 cites W2006728188 @default.
• W2138897907 cites W2013007443 @default.
• W2138897907 cites W2013561452 @default.
• W2138897907 cites W2019656247 @default.
• W2138897907 cites W2023449463 @default.
• W2138897907 cites W2030022427 @default.
• W2138897907 cites W2047964022 @default.
• W2138897907 cites W2048660395 @default.
• W2138897907 cites W2056973414 @default.
• W2138897907 cites W2059341662 @default.
• W2138897907 cites W2070926750 @default.
• W2138897907 cites W2073706613 @default.
• W2138897907 cites W2077034296 @default.
• W2138897907 cites W2083040958 @default.
• W2138897907 cites W2084536221 @default.
• W2138897907 cites W2086959096 @default.
• W2138897907 cites W2090747573 @default.
• W2138897907 cites W2098227836 @default.
• W2138897907 cites W2104938297 @default.
• W2138897907 cites W2106697731 @default.
• W2138897907 cites W2113999599 @default.
• W2138897907 cites W2129741075 @default.
• W2138897907 cites W2130892097 @default.
• W2138897907 cites W2130961250 @default.
• W2138897907 cites W2137746742 @default.
• W2138897907 cites W2140676951 @default.
• W2138897907 cites W2142233913 @default.
• W2138897907 cites W2145124208 @default.
• W2138897907 cites W2150161054 @default.
• W2138897907 cites W2151918708 @default.
• W2138897907 cites W2153393998 @default.
• W2138897907 cites W2154229994 @default.
• W2138897907 cites W2167340008 @default.
• W2138897907 cites W2169957659 @default.
• W2138897907 cites W2319982677 @default.
• W2138897907 cites W2471605942 @default.
• W2138897907 doi "https://doi.org/10.1016/j.bbamcr.2008.08.010" @default.
• W2138897907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18822320" @default.
• W2138897907 hasPublicationYear "2008" @default.
• W2138897907 type Work @default.
• W2138897907 sameAs 2138897907 @default.
• W2138897907 citedByCount "18" @default.
• W2138897907 countsByYear W21388979072013 @default.
• W2138897907 countsByYear W21388979072014 @default.
• W2138897907 countsByYear W21388979072015 @default.
• W2138897907 countsByYear W21388979072016 @default.
• W2138897907 countsByYear W21388979072017 @default.
• W2138897907 countsByYear W21388979072018 @default.
• W2138897907 countsByYear W21388979072020 @default.
• W2138897907 countsByYear W21388979072021 @default.
• W2138897907 countsByYear W21388979072023 @default.
• W2138897907 crossrefType "journal-article" @default.
• W2138897907 hasAuthorship W2138897907A5001389064 @default.
• W2138897907 hasAuthorship W2138897907A5007909935 @default.
• W2138897907 hasAuthorship W2138897907A5022840246 @default.
• W2138897907 hasAuthorship W2138897907A5031542615 @default.
• W2138897907 hasAuthorship W2138897907A5068179878 @default.
• W2138897907 hasBestOaLocation W21388979071 @default.
• W2138897907 hasConcept C147990577 @default.
• W2138897907 hasConcept C169760540 @default.
• W2138897907 hasConcept C170493617 @default.
• W2138897907 hasConcept C185592680 @default.
• W2138897907 hasConcept C190283241 @default.
• W2138897907 hasConcept C203014093 @default.
• W2138897907 hasConcept C2775934118 @default.
• W2138897907 hasConcept C2778857457 @default.
• W2138897907 hasConcept C2779726688 @default.
• W2138897907 hasConcept C28406088 @default.
• W2138897907 hasConcept C28859421 @default.
• W2138897907 hasConcept C29311851 @default.
• W2138897907 hasConcept C31573885 @default.
• W2138897907 hasConcept C55493867 @default.
• W2138897907 hasConcept C86803240 @default.
• W2138897907 hasConcept C88634738 @default.
• W2138897907 hasConcept C95444343 @default.
• W2138897907 hasConceptScore W2138897907C147990577 @default.
• W2138897907 hasConceptScore W2138897907C169760540 @default.

• next