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- W2138906088 abstract "Sequences rich in glutamine (Q) and asparagine (N) residues often fail to fold at the monomer level. This, coupled to their unusual hydrogen-bonding abilities, provides the driving force to switch between disordered monomers and amyloids. Such transitions govern processes as diverse as human protein-folding diseases, bacterial biofilm assembly, and the inheritance of yeast prions (protein-based genetic elements). A systematic survey of prion-forming domains suggested that Q and N residues have distinct effects on amyloid formation. Here, we use cell biological, biochemical, and computational techniques to compare Q/N-rich protein variants, replacing Ns with Qs and Qs with Ns. We find that the two residues have strong and opposing effects: N richness promotes assembly of benign self-templating amyloids; Q richness promotes formation of toxic nonamyloid conformers. Molecular simulations focusing on intrinsic folding differences between Qs and Ns suggest that their different behaviors are due to the enhanced turn-forming propensity of Ns over Qs." @default.
- W2138906088 created "2016-06-24" @default.
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- W2138906088 date "2011-07-01" @default.
- W2138906088 modified "2023-10-06" @default.
- W2138906088 title "Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins" @default.
- W2138906088 cites W1503622815 @default.
- W2138906088 cites W1510294009 @default.
- W2138906088 cites W1548441884 @default.
- W2138906088 cites W1894729831 @default.
- W2138906088 cites W1967036562 @default.
- W2138906088 cites W1970434234 @default.
- W2138906088 cites W1970578578 @default.
- W2138906088 cites W1971222918 @default.
- W2138906088 cites W1971803615 @default.
- W2138906088 cites W1973151317 @default.
- W2138906088 cites W1975769486 @default.
- W2138906088 cites W1977677374 @default.
- W2138906088 cites W1978794287 @default.
- W2138906088 cites W1979706337 @default.
- W2138906088 cites W1983993803 @default.
- W2138906088 cites W1985474993 @default.
- W2138906088 cites W1985968682 @default.
- W2138906088 cites W1992119552 @default.
- W2138906088 cites W1993027148 @default.
- W2138906088 cites W1994947657 @default.
- W2138906088 cites W2000204824 @default.
- W2138906088 cites W2001127343 @default.
- W2138906088 cites W2006654567 @default.
- W2138906088 cites W2006934202 @default.
- W2138906088 cites W2009568691 @default.
- W2138906088 cites W2011163535 @default.
- W2138906088 cites W2012385113 @default.
- W2138906088 cites W2013112316 @default.
- W2138906088 cites W2016829947 @default.
- W2138906088 cites W2022793853 @default.
- W2138906088 cites W2024645073 @default.
- W2138906088 cites W2027839322 @default.
- W2138906088 cites W2031382376 @default.
- W2138906088 cites W2034170455 @default.
- W2138906088 cites W2037751823 @default.
- W2138906088 cites W2039329450 @default.
- W2138906088 cites W2043676526 @default.
- W2138906088 cites W2049476357 @default.
- W2138906088 cites W2058236814 @default.
- W2138906088 cites W2064077469 @default.
- W2138906088 cites W2068334126 @default.
- W2138906088 cites W2070496155 @default.
- W2138906088 cites W2072613948 @default.
- W2138906088 cites W2073533352 @default.
- W2138906088 cites W2076468390 @default.
- W2138906088 cites W2077745997 @default.
- W2138906088 cites W2077790507 @default.
- W2138906088 cites W2088180120 @default.
- W2138906088 cites W2094384279 @default.
- W2138906088 cites W2095782512 @default.
- W2138906088 cites W2098898403 @default.
- W2138906088 cites W2100630099 @default.
- W2138906088 cites W2111149100 @default.
- W2138906088 cites W2112650804 @default.
- W2138906088 cites W2114123446 @default.
- W2138906088 cites W2114358470 @default.
- W2138906088 cites W2115425931 @default.
- W2138906088 cites W2116592258 @default.
- W2138906088 cites W2117709367 @default.
- W2138906088 cites W2118557791 @default.
- W2138906088 cites W2119651404 @default.
- W2138906088 cites W2121753059 @default.
- W2138906088 cites W2121963977 @default.
- W2138906088 cites W2129602427 @default.
- W2138906088 cites W2137220407 @default.
- W2138906088 cites W2138987038 @default.
- W2138906088 cites W2143495798 @default.
- W2138906088 cites W2146865209 @default.
- W2138906088 cites W2149996174 @default.
- W2138906088 cites W2150784670 @default.
- W2138906088 cites W2154335467 @default.
- W2138906088 cites W2160779871 @default.
- W2138906088 cites W2161409639 @default.
- W2138906088 cites W2162057703 @default.
- W2138906088 cites W2162685411 @default.
- W2138906088 cites W2165187711 @default.
- W2138906088 cites W2165724034 @default.
- W2138906088 cites W2169033090 @default.
- W2138906088 doi "https://doi.org/10.1016/j.molcel.2011.05.013" @default.
- W2138906088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3132398" @default.
- W2138906088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21726811" @default.
- W2138906088 hasPublicationYear "2011" @default.
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