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• W2138914317 endingPage "381" @default.
• W2138914317 startingPage "368" @default.
• W2138914317 abstract "Summary Competence for genetic transformation in the bacterium Bacillus subtilis is a bistable differentiation process governed by the minor groove DNA binding protein ComK. No detectable comK transcription occurs in the absence of an intact comK gene, indicating that ComK has auto‐activating properties. ComK auto‐stimulation, which is dependent on ComK binding to the comK promoter, is a critical step in competence development, ensuring quick and high‐level expression of the late‐competence genes. Auto‐stimulation is also essential for the bistable expression pattern of competence. Here, we demonstrate that ComK acts as an activator at its own promoter by antagonizing the action of two repressors, Rok and CodY. Importantly, antirepression occurs without preventing binding of the repressing proteins, suggesting that ComK and the repressors might bind at distinct surfaces of the DNA helix. DegU, a DNA binding protein known to increase the affinity of ComK for its own promoter, potentiates the antirepression activity of ComK. We postulate that antirepression is primarily achieved through modulation of DNA topology. Although to our knowledge ComK is the only DNA binding protein shown to act in this novel fashion, other minor groove binding proteins may act similarly." @default.
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• W2138914317 date "2007-04-01" @default.
• W2138914317 modified "2023-10-12" @default.
• W2138914317 title "Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein" @default.
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• W2138914317 doi "https://doi.org/10.1111/j.1365-2958.2007.05662.x" @default.
• W2138914317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3831528" @default.
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