FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138920002> ?p ?o ?g. }

• W2138920002 abstract "Animal models of psychiatric disorders are usually discussed with regard to three criteria first elaborated by Willner; face, predictive and construct validity. Here, we draw the history of these concepts and then try to redraw and refine these criteria, using the framework of the diathesis model of depression that has been proposed by several authors. We thus propose a set of five major criteria (with sub-categories for some of them); homological validity (including species validity and strain validity), pathogenic validity (including ontopathogenic validity and triggering validity), mechanistic validity, face validity (including ethological and biomarker validity) and predictive validity (including induction and remission validity). Homological validity requires that an adequate species and strain be chosen: considering species validity, primates will be considered to have a higher score than drosophila, and considering strains, a high stress reactivity in a strain scores higher than a low stress reactivity in another strain. Pathological validity corresponds to the fact that, in order to shape pathological characteristics, the organism has been manipulated both during the developmental period (for example, maternal separation: ontopathogenic validity) and during adulthood (for example, stress: triggering validity). Mechanistic validity corresponds to the fact that the cognitive (for example, cognitive bias) or biological mechanisms (such as dysfunction of the hormonal stress axis regulation) underlying the disorder are identical in both humans and animals. Face validity corresponds to the observable behavioral (ethological validity) or biological (biomarker validity) outcomes: for example anhedonic behavior (ethological validity) or elevated corticosterone (biomarker validity). Finally, predictive validity corresponds to the identity of the relationship between the triggering factor and the outcome (induction validity) and between the effects of the treatments on the two organisms (remission validity). The relevance of this framework is then discussed regarding various animal models of depression." @default.
• W2138920002 created "2016-06-24" @default.
• W2138920002 creator A5038701086 @default.
• W2138920002 creator A5052883373 @default.
• W2138920002 date "2011-11-07" @default.
• W2138920002 modified "2023-10-02" @default.
• W2138920002 title "Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression" @default.
• W2138920002 cites W1482632432 @default.
• W2138920002 cites W1545745337 @default.
• W2138920002 cites W1871731410 @default.
• W2138920002 cites W1964218847 @default.
• W2138920002 cites W1976073163 @default.
• W2138920002 cites W1981654563 @default.
• W2138920002 cites W1983584957 @default.
• W2138920002 cites W1989140838 @default.
• W2138920002 cites W1999790101 @default.
• W2138920002 cites W2004118951 @default.
• W2138920002 cites W2014099101 @default.
• W2138920002 cites W2023343492 @default.
• W2138920002 cites W2030772288 @default.
• W2138920002 cites W2031603167 @default.
• W2138920002 cites W2040103405 @default.
• W2138920002 cites W2044842298 @default.
• W2138920002 cites W2052391790 @default.
• W2138920002 cites W2056835885 @default.
• W2138920002 cites W2056994786 @default.
• W2138920002 cites W2064258379 @default.
• W2138920002 cites W2067950747 @default.
• W2138920002 cites W2075567703 @default.
• W2138920002 cites W2079894500 @default.
• W2138920002 cites W2081302124 @default.
• W2138920002 cites W2086983843 @default.
• W2138920002 cites W2087548521 @default.
• W2138920002 cites W2088814233 @default.
• W2138920002 cites W2092499931 @default.
• W2138920002 cites W2109621861 @default.
• W2138920002 cites W2113457968 @default.
• W2138920002 cites W2132058857 @default.
• W2138920002 cites W2137666662 @default.
• W2138920002 cites W2143966041 @default.
• W2138920002 cites W2148239264 @default.
• W2138920002 cites W2155697728 @default.
• W2138920002 cites W2168795031 @default.
• W2138920002 cites W2325683129 @default.
• W2138920002 cites W2489160666 @default.
• W2138920002 doi "https://doi.org/10.1186/2045-5380-1-9" @default.
• W2138920002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3384226" @default.
• W2138920002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22738250" @default.
• W2138920002 hasPublicationYear "2011" @default.
• W2138920002 type Work @default.
• W2138920002 sameAs 2138920002 @default.
• W2138920002 citedByCount "279" @default.
• W2138920002 countsByYear W21389200022012 @default.
• W2138920002 countsByYear W21389200022013 @default.
• W2138920002 countsByYear W21389200022014 @default.
• W2138920002 countsByYear W21389200022015 @default.
• W2138920002 countsByYear W21389200022016 @default.
• W2138920002 countsByYear W21389200022017 @default.
• W2138920002 countsByYear W21389200022018 @default.
• W2138920002 countsByYear W21389200022019 @default.
• W2138920002 countsByYear W21389200022020 @default.
• W2138920002 countsByYear W21389200022021 @default.
• W2138920002 countsByYear W21389200022022 @default.
• W2138920002 countsByYear W21389200022023 @default.
• W2138920002 crossrefType "journal-article" @default.
• W2138920002 hasAuthorship W2138920002A5038701086 @default.
• W2138920002 hasAuthorship W2138920002A5052883373 @default.
• W2138920002 hasBestOaLocation W21389200021 @default.
• W2138920002 hasConcept C116211729 @default.
• W2138920002 hasConcept C118552586 @default.
• W2138920002 hasConcept C120107772 @default.
• W2138920002 hasConcept C121244757 @default.
• W2138920002 hasConcept C15744967 @default.
• W2138920002 hasConcept C171606756 @default.
• W2138920002 hasConcept C174106493 @default.
• W2138920002 hasConcept C180747234 @default.
• W2138920002 hasConcept C182050348 @default.
• W2138920002 hasConcept C198999979 @default.
• W2138920002 hasConcept C20685875 @default.
• W2138920002 hasConcept C3018868096 @default.
• W2138920002 hasConcept C33191230 @default.
• W2138920002 hasConcept C49453240 @default.
• W2138920002 hasConcept C558461103 @default.
• W2138920002 hasConcept C70364389 @default.
• W2138920002 hasConcept C70410870 @default.
• W2138920002 hasConcept C77805123 @default.
• W2138920002 hasConcept C90963130 @default.
• W2138920002 hasConceptScore W2138920002C116211729 @default.
• W2138920002 hasConceptScore W2138920002C118552586 @default.
• W2138920002 hasConceptScore W2138920002C120107772 @default.
• W2138920002 hasConceptScore W2138920002C121244757 @default.
• W2138920002 hasConceptScore W2138920002C15744967 @default.
• W2138920002 hasConceptScore W2138920002C171606756 @default.
• W2138920002 hasConceptScore W2138920002C174106493 @default.
• W2138920002 hasConceptScore W2138920002C180747234 @default.
• W2138920002 hasConceptScore W2138920002C182050348 @default.
• W2138920002 hasConceptScore W2138920002C198999979 @default.
• W2138920002 hasConceptScore W2138920002C20685875 @default.
• W2138920002 hasConceptScore W2138920002C3018868096 @default.
• W2138920002 hasConceptScore W2138920002C33191230 @default.

• next