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• W2138980643 abstract "No AccessJournal of UrologySociety of Urologic Oncology1 Aug 1999STATISTICAL CONSIDERATIONS WHEN ASSESSING OUTCOMES FOLLOWING TREATMENT FOR PROSTATE CANCER PETER C. ALBERTSEN, JAMES A. HANLEY, and MARLENE MURPHY-SETZKO PETER C. ALBERTSENPETER C. ALBERTSEN More articles by this author , JAMES A. HANLEYJAMES A. HANLEY More articles by this author , and MARLENE MURPHY-SETZKOMARLENE MURPHY-SETZKO More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68580-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We explore the impact of study designs, biases, outcome variables and statistical techniques when interpreting studies concerning prostate cancer management. Materials and Methods: Examples from the current literature and a recently assembled population based sample of patients 55 to 75 years old at diagnosis identified by the Connecticut Tumor Registry as having newly diagnosed localized prostate cancer between 1971 and 1984 are provided to assist the reader to understand the principles discussed. Results: Most reports concerning prostate cancer outcomes suffer from obvious and subtle biases that confound the reader's understanding of the impact of different treatment alternatives. Conclusions: By remaining vigilant to these confounding issues, clinicians and patients can gain greater insights into the medical literature and can make individual interpretations concerning the potential impact of treatment interventions on men with prostate cancer. References 1 : Cancer statistics, 1998. Cancer J. Clin.1998; 48: 6. 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Outcomes for men with clinically nonmetastatic prostate cancer managed with radical prostatectomy, external beam radiotherapy, or expectant management: a retrospective, intention-to-treat analysis with standardized assessments of state, grade and comorbidity. Submitted for publication, 1998 Google Scholar 8 : The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. New Engl. J. Med.1985; 312: 1604. Google Scholar 9 : Long-term survival and mortality in prostate cancer treated with noncurative intent. J. Urol.1995; 154: 460. Link, Google Scholar 10 : Re: Long-term survival and mortality in prostate cancer treated with noncurative intent. J. Urol.1996; 155: 296. Link, Google Scholar 11 : Fifteen-year survival in prostate cancer. A prospective, population-based study in Sweden. J.A.M.A.1977; 277: 467. Google Scholar 12 : Results of conservative management of clinically localized prostate cancer. New Engl. J. Med.1994; 330: 242. Crossref, Medline, Google Scholar 13 : Long-term survival among men with conservatively treated localized prostate cancer. J.A.M.A.1995; 274: 626. Google Scholar 14 : Extended followup of the influence of wide excision of the neurovascular bundles on prognosis in men with clinically localized prostate cancer and extensive capsular perforation. J. Urol.1996; 156: 454. Link, Google Scholar 15 : Cancer control and quality of life following anatomical radical retropubic prostatectomy: results at 10 years. J. Urol.1994; 152: 1831. Link, Google Scholar 16 : Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. J.A.M.A.1997; 277: 1445. Google Scholar 17 : Follow up prostate cancer treatments after radical prostatectomy-a population based study. J. Natl. Cancer Inst1996; 88: 166. 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Google Scholar From the Division of Urology, University of Connecticut Health Center, Farmington, Connecticut, and Department of Epidemiology and Biostatistics, McGill University, Montreal, PQ, Canada© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAlbertsen P, Hanley J, Penson D, Barrows G and Fine J (2018) 13-Year Outcomes Following Treatment for Clinically Localized Prostate Cancer in a Population Based CohortJournal of Urology, VOL. 177, NO. 3, (932-936), Online publication date: 1-Mar-2007.Scales C, Peterson B and Dahm P (2018) Interpreting Statistics in the Urological LiteratureJournal of Urology, VOL. 176, NO. 5, (1938-1945), Online publication date: 1-Nov-2006.Sur R, Scales C, Preminger G and Dahm P (2018) Evidence-Based Medicine: A Survey of American Urological Association MembersJournal of Urology, VOL. 176, NO. 3, (1127-1134), Online publication date: 1-Sep-2006.OEFELEIN M and RESNICK M (2018) ASSOCIATION OF TOBACCO USE WITH HORMONE REFRACTORY DISEASE AND SURVIVAL OF PATIENTS WITH PROSTATE CANCERJournal of Urology, VOL. 171, NO. 6 Part 1, (2281-2284), Online publication date: 1-Jun-2004.OEFELEIN M, AGARWAL P and RESNICK M (2018) SURVIVAL OF PATIENTS WITH HORMONE REFRACTORY PROSTATE CANCER IN THE PROSTATE SPECIFIC ANTIGEN ERAJournal of Urology, VOL. 171, NO. 4, (1525-1528), Online publication date: 1-Apr-2004.Oefelein M, Ricchiuti V, Conrad W and Resnick M (2018) Skeletal Fractures Negatively Correlate With Overall Survival in Men With Prostate CancerJournal of Urology, VOL. 168, NO. 3, (1005-1007), Online publication date: 1-Sep-2002. Volume 162Issue 2August 1999Page: 439-444 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information PETER C. ALBERTSEN More articles by this author JAMES A. HANLEY More articles by this author MARLENE MURPHY-SETZKO More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2138980643 title "STATISTICAL CONSIDERATIONS WHEN ASSESSING OUTCOMES FOLLOWING TREATMENT FOR PROSTATE CANCER" @default.
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