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• W2138992810 abstract "Significance This manuscript links ApoE4-mediated signaling with Sirtuin function. Specifically, we show that ApoE4, but not ApoE3, reduces neuroprotective SirT1 levels. Our data support the hypothesis that neuronal connectivity, as reflected in the ratios of critical mediators such as sAPPα:Aβ, SirT1:SirT2, APP:p-APP, and Tau:p-Tau, is programmatically altered by ApoE4. Thus ApoE4, SirT1/2, p-Tau, and p-APP, all may be part of a signaling network that is affected in AD, providing a model for therapeutic candidate screening in AD drug discovery. These findings offer a unique insight into the mechanism by which ApoE4 confers risk for the development of Alzheimer’s disease." @default.
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• W2138992810 date "2013-10-21" @default.
• W2138992810 modified "2023-10-12" @default.
• W2138992810 title "Neuroprotective Sirtuin ratio reversed by ApoE4" @default.
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• W2138992810 doi "https://doi.org/10.1073/pnas.1314145110" @default.
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