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- W2139005937 abstract "When Escherichia coli grows in the presence of DNA-damaging agents such as methyl methanesulphonate (MMS), absence of the full-length form of Translation Initiation Factor 2 (IF2-1) or deficiency in helicase activity of replication restart protein PriA leads to a considerable loss of viability. MMS sensitivity of these mutants was contingent on the stringent response alarmone (p)ppGpp being at low levels. While zero levels (ppGpp°) greatly aggravated sensitivity, high levels promoted resistance. Moreover, M+ mutations, which suppress amino acid auxotrophy of ppGpp° strains and which have been found to map to RNA polymerase subunits, largely restored resistance to IF2-1- and PriA helicase-deficient mutants. The truncated forms IF2-2/3 played a key part in inducing especially severe negative effects in ppGpp° cells when restart function priB was knocked out, causing loss of viability and severe cell filamentation, indicative of SOS induction. Even a strain with the wild-type infB allele exhibited significant filamentation and MMS sensitivity in this background whereas mutations that prevent expression of IF2-2/3 essentially eliminated filamentation and largely restored MMS resistance. The results suggest different influences of IF2-1 and IF2-2/3 on the replication restart system depending on (p)ppGpp levels, each having the capacity to maximize survival under differing growth conditions." @default.
- W2139005937 created "2016-06-24" @default.
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- W2139005937 date "2014-02-28" @default.
- W2139005937 modified "2023-10-02" @default.
- W2139005937 title "Stringent response processes suppress DNA damage sensitivity caused by deficiency in full-length translation initiation factor 2 or PriA helicase" @default.
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- W2139005937 doi "https://doi.org/10.1111/mmi.12538" @default.
- W2139005937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4008491" @default.
- W2139005937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24612328" @default.
- W2139005937 hasPublicationYear "2014" @default.
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