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- W2139006226 abstract "Copyright: © 2013 Lawson K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fibromyalgia (FM) is a chronic condition that presents with a complex of symptoms that include widespread pain, fatigue, dysfunctional sleep and cognitive disruption [1]. The prevalence of this condition is reported to be 2-4% of the population in developed countries, increasing to greater than 7% of those over 70 years of age. As a consequence this presents as a major financial and social burden to patients with FM, their families and carers, and to healthcare systems. FM was classified by the American College of Rheumatology (ACR) in 1990 as widespread pain for at least 3 months and tenderness in at least 11 of 18 defined tender points [2]. The ACR criteria recognise patients with severe pain symptoms, but fail to assess the other symptoms and fulfilment for diagnosis has been suggested to miss 46% of patients with FM [3]. The subjective nature of the tender-point requirement has therefore led to its omission in the current 2010 ACR diagnostic criteria [4]. Significant progress in the understanding of the pathophysiology and identification of effective treatments of FM has been made recently [1,5]. FM is described as a condition of heightened generalized sensitization to sensory input presenting as a complex of symptoms, including pain, where the pathophysiology could include dysfunction of the CNS pain modulatory systems, dysfunction of the neuroendocrine system, and dysautonomia [1,5]. A primary pathophysiological mechanism involves excessive nociceptive neurotransmitter function in the ascending pain signaling pathway in the central nervous system accompanied by a dysfunction in the descending modulatory pathway between the brain and the dorsal horn of the spinal [5]." @default.
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- W2139006226 date "2013-01-01" @default.
- W2139006226 modified "2023-09-27" @default.
- W2139006226 title "Innovative Approaches for the Complexity of Fibromyalgia" @default.
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- W2139006226 doi "https://doi.org/10.4172/2161-1459.1000e126" @default.
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