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• W213900652 abstract "T-cell receptors (TCR) and immunoglobulins (Ig) are somatically diversified through an active process; the status of the repertoire diversity in these antigen receptors provides an insight into the immune health of the subject and a window onto the dynamical workings of lymphocyte population dynamics. One measure of this diversity is the distribution of lengths of the third complementary-determining region (CDR3) of TCR and Ig. Antigenreceptor spectratype analysis is the technique commonly used to measure this distribution, and thereby the receptor repertoire diversity for basic immunological experiments and medical procedures, notably hematopoietic stem-cell and lymphoid tissue transplantations. A web-accessible spectratype analysis (SpA) has been developed for data management, statistical analysis, and visualization of TCR and Ig spectratype data of human and mouse subjects. Users upload spectratype data from their analyzer to SpA, which saves the raw data and user-defined and user-supplied supplementary covariates to a secure database. The analysis engine performs several data analyses, providing estimated relative frequencies, and summary statistics. The visualization engine presents analyzed histogram results in a Java applet and a PNG (Portable Network Graphics) image. Relevant statistics, histogram data, and processing data are also provided for downloading or online browsing. One of the statistics provided, the Kullback-Leibler divergence (DKL), is an objective measure of the level of TCR diversity. Given spectratypes obtained from different dates, SpA can produce a plot of DKL vs. time giving a convenient visual representation of the progression of TCR diversity over the course of a treatment study. This paper presents an analysis of the development of TCR diversity in a patient with complete DiGeorge syndrome (lacking all thymic function) who has undergone thymus tissue transplantation for T cell reconstitution. Availability: The SpA service is freely accessible at https://spa.dulci.org/. Additional technical support and specialized statistical analysis and consultation are available by arrangement with the authors and, depending on the service requested, may be subject to fee." @default.
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• W213900652 date "2006-01-01" @default.
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• W213900652 title "SpA: Web-accessible Spectratype Analysis: Application to Investigate the Development of TCR Diversity in a Patient with Complete DiGeorge Syndrome." @default.
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