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• W2139025888 startingPage "2584" @default.
• W2139025888 abstract "Sex Comb on Midleg (SCM) is a transcriptional repressor in the Polycomb group (PcG), but its molecular role in PcG silencing is not known. Although SCM can interact with Polycomb repressive complex 1 (PRC1) in vitro, biochemical studies have indicated that SCM is not a core constituent of PRC1 or PRC2. Nevertheless, SCM is just as critical for Drosophila Hox gene silencing as canonical subunits of these well-characterized PcG complexes. To address functional relationships between SCM and other PcG components, we have performed chromatin immunoprecipitation studies using cultured Drosophila Schneider line 2 (S2) cells and larval imaginal discs. We find that SCM associates with a Polycomb response element (PRE) upstream of the Ubx gene which also binds PRC1, PRC2, and the DNA-binding PcG protein Pleiohomeotic (PHO). However, SCM is retained at this Ubx PRE despite genetic disruption or knockdown of PHO, PRC1, or PRC2, suggesting that SCM chromatin targeting does not require prior association of these other PcG components. Chromatin immunoprecipitations (IPs) to test the consequences of SCM genetic disruption or knockdown revealed that PHO association is unaffected, but reduced levels of PRE-bound PRC2 and PRC1 were observed. We discuss these results in light of current models for recruitment of PcG complexes to chromatin targets." @default.
• W2139025888 created "2016-06-24" @default.
• W2139025888 creator A5038657321 @default.
• W2139025888 creator A5043018818 @default.
• W2139025888 creator A5047741511 @default.
• W2139025888 creator A5051096995 @default.
• W2139025888 creator A5076959287 @default.
• W2139025888 creator A5085054720 @default.
• W2139025888 date "2010-06-01" @default.
• W2139025888 modified "2023-10-11" @default.
• W2139025888 title "Comparative Analysis of Chromatin Binding by Sex Comb on Midleg (SCM) and Other Polycomb Group Repressors at a <i>Drosophila Hox</i> Gene" @default.
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