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• W2139046754 abstract "Transdermal delivery systems are useful in cases where preferred routes such as the oral route are not available. However, low overall extent of delivery is seen due to the permeation barrier posed by the skin. Chemical penetration enhancers and invasive methods that disturb the structural barrier function of the skin can be used to improve transdermal drug delivery. However, for suitable drugs, a fast-releasing transdermal delivery system can be produced by incorporating a heating source into a transdermal patch. In this study, a molecular dynamics simulation showed that heat increased the diffusivity of the drug molecules, resulting in faster release from gels containing ketoprofen, diclofenac sodium, and lidocaine HCl. Simulations were confirmed by in vitro drug release studies through lipophilic membranes. These correlations could expand the application of heated transdermal delivery systems for use as fast-release-dosage forms." @default.
• W2139046754 created "2016-06-24" @default.
• W2139046754 creator A5042305207 @default.
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• W2139046754 date "2012-12-11" @default.
• W2139046754 modified "2023-10-03" @default.
• W2139046754 title "The Experimental Evaluation and Molecular Dynamics Simulation of a Heat-Enhanced Transdermal Delivery System" @default.
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• W2139046754 doi "https://doi.org/10.1208/s12249-012-9900-6" @default.
• W2139046754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3581683" @default.
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