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- W2139063458 abstract "Background: Co-existent cardiac and renal dysfunction is increasingly recognized as both a predictor and mediator of poor outcomes in patients with advanced heart failure. Novel therapies, including adenosine receptor antagonists, are currently under development for the treatment of ‘cardiorenal syndrome’. Objectives: To review the pathophysiologic rationale for using rolofylline, a selective adenosine 1 receptor antagonist, in patients with cardiorenal syndrome; and to provide a critical overview of safety and efficacy data from clinical studies. Methods: We reviewed published data on the pharmacology of rolofylline, and used this to inform a comprehensive summary of preclinical and clinical trials. Cardiac and renal effects, and safety data with a particular reference to seizures, are highlighted. Results/conclusion: Rolofylline facilitates diuresis and preserves renal function in patients with acute decompensated heart failure and renal dysfunction. Pilot data also suggest beneficial effects on symptoms and short-term outcomes. The risk of seizures may be minimized by excluding high-risk patients." @default.
- W2139063458 created "2016-06-24" @default.
- W2139063458 creator A5015244767 @default.
- W2139063458 creator A5088310205 @default.
- W2139063458 date "2009-01-20" @default.
- W2139063458 modified "2023-09-25" @default.
- W2139063458 title "Rolofylline: a selective adenosine 1 receptor antagonist for the treatment of heart failure" @default.
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- W2139063458 doi "https://doi.org/10.1517/14656560802682213" @default.
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