Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139071718> ?p ?o ?g. }
- W2139071718 endingPage "620" @default.
- W2139071718 startingPage "613" @default.
- W2139071718 abstract "Background QT interval prolongation, a predictor of cardiac arrhythmias, and elevated heart rate are associated with higher risk of cardiovascular mortality. Observationally testosterone is associated with shorter corrected QT interval and slower heart rate; however, the evidence is open to residual confounding and reverse causality. We examined the association of testosterone with electrocardiogram (ECG) parameters using a separate-sample instrumental variable (SSIV) estimator. Methods To minimize reverse causality, a genetic score predicting testosterone was developed in 289 young Chinese men from Hong Kong, based on a parsimonious set of single nuclear polymorphisms (rs10046, rs1008805 and rs1256031). Linear regression was used to examine the association of genetically predicted testosterone with QT interval, corrected QT interval [using the Framingham formula (QTf) and Bazett formula (QTb)] and heart rate in 4212 older (50+ years) Chinese men from the Guangzhou Biobank Cohort Study. Results Predicted testosterone was not associated with QT interval [−0.08 ms per nmol/l testosterone, 95% confidence interval (CI) −0.81 to 0.65], QTf interval (0.40 ms per nmol/l testosterone, 95% CI −0.12 to 0.93) or heart rate (0.26 beats per minute per nmol/l testosterone, 95% CI −0.04 to 0.56), but was associated with longer QTb interval (0.66 ms per nmol/l testosterone, 95% CI 0.02 to 1.31). Conclusions Our findings do not corroborate observed protective associations of testosterone with QT interval or heart rate among men, but potentially suggest effects in the other direction. Replication in a larger sample is required." @default.
- W2139071718 created "2016-06-24" @default.
- W2139071718 creator A5019779203 @default.
- W2139071718 creator A5020377532 @default.
- W2139071718 creator A5022209651 @default.
- W2139071718 creator A5024925889 @default.
- W2139071718 creator A5034713094 @default.
- W2139071718 creator A5036765539 @default.
- W2139071718 creator A5048826252 @default.
- W2139071718 creator A5054664845 @default.
- W2139071718 creator A5060005501 @default.
- W2139071718 creator A5074062230 @default.
- W2139071718 date "2014-12-14" @default.
- W2139071718 modified "2023-10-01" @default.
- W2139071718 title "Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study" @default.
- W2139071718 cites W1566014863 @default.
- W2139071718 cites W1789825492 @default.
- W2139071718 cites W1970097733 @default.
- W2139071718 cites W1983727766 @default.
- W2139071718 cites W1991290782 @default.
- W2139071718 cites W1993832391 @default.
- W2139071718 cites W2005147855 @default.
- W2139071718 cites W2008406326 @default.
- W2139071718 cites W2009480731 @default.
- W2139071718 cites W2012684316 @default.
- W2139071718 cites W2012882079 @default.
- W2139071718 cites W2016100897 @default.
- W2139071718 cites W2016130920 @default.
- W2139071718 cites W2024280216 @default.
- W2139071718 cites W2035126508 @default.
- W2139071718 cites W2038201411 @default.
- W2139071718 cites W2054492310 @default.
- W2139071718 cites W2059133379 @default.
- W2139071718 cites W2068541344 @default.
- W2139071718 cites W2070166705 @default.
- W2139071718 cites W2072378777 @default.
- W2139071718 cites W2078034341 @default.
- W2139071718 cites W2078673077 @default.
- W2139071718 cites W2090072574 @default.
- W2139071718 cites W2091676929 @default.
- W2139071718 cites W2093498393 @default.
- W2139071718 cites W2099814945 @default.
- W2139071718 cites W2101578104 @default.
- W2139071718 cites W2101969517 @default.
- W2139071718 cites W2102011776 @default.
- W2139071718 cites W2110318301 @default.
- W2139071718 cites W2118047070 @default.
- W2139071718 cites W2118586907 @default.
- W2139071718 cites W2125371786 @default.
- W2139071718 cites W2125439972 @default.
- W2139071718 cites W2127768736 @default.
- W2139071718 cites W2132416815 @default.
- W2139071718 cites W2136598972 @default.
- W2139071718 cites W2137467802 @default.
- W2139071718 cites W2137939611 @default.
- W2139071718 cites W2139498473 @default.
- W2139071718 cites W2143003039 @default.
- W2139071718 cites W2148782448 @default.
- W2139071718 cites W2151872224 @default.
- W2139071718 cites W2162425761 @default.
- W2139071718 cites W2163028364 @default.
- W2139071718 cites W2165285926 @default.
- W2139071718 cites W4253765088 @default.
- W2139071718 doi "https://doi.org/10.1093/ije/dyu241" @default.
- W2139071718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25502105" @default.
- W2139071718 hasPublicationYear "2014" @default.
- W2139071718 type Work @default.
- W2139071718 sameAs 2139071718 @default.
- W2139071718 citedByCount "12" @default.
- W2139071718 countsByYear W21390717182015 @default.
- W2139071718 countsByYear W21390717182016 @default.
- W2139071718 countsByYear W21390717182017 @default.
- W2139071718 countsByYear W21390717182018 @default.
- W2139071718 countsByYear W21390717182021 @default.
- W2139071718 countsByYear W21390717182022 @default.
- W2139071718 crossrefType "journal-article" @default.
- W2139071718 hasAuthorship W2139071718A5019779203 @default.
- W2139071718 hasAuthorship W2139071718A5020377532 @default.
- W2139071718 hasAuthorship W2139071718A5022209651 @default.
- W2139071718 hasAuthorship W2139071718A5024925889 @default.
- W2139071718 hasAuthorship W2139071718A5034713094 @default.
- W2139071718 hasAuthorship W2139071718A5036765539 @default.
- W2139071718 hasAuthorship W2139071718A5048826252 @default.
- W2139071718 hasAuthorship W2139071718A5054664845 @default.
- W2139071718 hasAuthorship W2139071718A5060005501 @default.
- W2139071718 hasAuthorship W2139071718A5074062230 @default.
- W2139071718 hasBestOaLocation W21390717181 @default.
- W2139071718 hasConcept C104317684 @default.
- W2139071718 hasConcept C111815664 @default.
- W2139071718 hasConcept C11783203 @default.
- W2139071718 hasConcept C118441451 @default.
- W2139071718 hasConcept C126322002 @default.
- W2139071718 hasConcept C134018914 @default.
- W2139071718 hasConcept C135763542 @default.
- W2139071718 hasConcept C164705383 @default.
- W2139071718 hasConcept C2777953023 @default.
- W2139071718 hasConcept C2779134260 @default.
- W2139071718 hasConcept C2779279991 @default.