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- W2139076385 abstract "Introduction Tissue engineering provides an alternative modality allowing for decreased morbidity of donor site grafting and decreased rejection of less compatible alloplastic tissues. Methods Using image-based design and computer software, a precisely sized and shaped scaffold for osseous tissue regeneration can be created via selective laser sintering. Polycaprolactone has been used to create a condylar ramus unit (CRU) scaffold for application in temporomandibular joint reconstruction in a Yucatan minipig animal model. Following sacrifice, micro-computed tomography and histology was used to demonstrate the efficacy of this particular scaffold design. Results A proof-of-concept surgery has demonstrated cartilaginous tissue regeneration along the articulating surface with exuberant osseous tissue formation. Bone volumes and tissue mineral density at both the 1 and 3 month time points demonstrated significant new bone growth interior and exterior to the scaffold. Conclusion Computationally designed scaffolds can support masticatory function in a large animal model as well as both osseous and cartilage regeneration. Our group is continuing to evaluate multiple implant designs in both young and mature Yucatan minipig animals. Copyright © 2007 John Wiley & Sons, Ltd." @default.
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- W2139076385 date "2007-01-01" @default.
- W2139076385 modified "2023-10-10" @default.
- W2139076385 title "Computed tomography-based tissue-engineered scaffolds in craniomaxillofacial surgery" @default.
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- W2139076385 doi "https://doi.org/10.1002/rcs.143" @default.
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