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- W2139083307 abstract "Therapy with tamoxifen has been shown to be associated with favorable changes in lipid profile. We examined the relationship between genetic polymorphisms in estrogen receptor genes (ER-alpha and ER-beta) and serum lipid profile in 82 women who were prescribed tamoxifen (20mg/day). The fasting serum lipid profiles were evaluated before starting tamoxifen therapy and at the end of four months of treatment. Pvu II and Xba I RFLPs were used to identify the IVS1-401 and IVS1-354 polymorphisms of ER-alpha. Genotyping for the ER-beta single nucleotide polymorphism located in 3' UTR (dbSNP ID: rs4986938) was performed by a TaqMan assay. After four months of tamoxifen therapy all women had significantly lower LDL-cholesterol compared to baseline and the effect appeared more pronounced in postmenopausal women (p=0.03 and <0.0001 for pre- and postmenopausal women respectively). In the postmenopausal women, those with ER-alpha IVS1-401 C/C genotype had significantly lower total and LDL-cholesterol when compared to those with C/T and T/T genotypes (p= 0.014 and 0.017 for total cholesterol and LDL-cholesterol respectively). In the subgroup of postmenopausal women with ER-alpha IVS1-401 C/C genotype, those carrying ER-beta G/G genotype (dbSNP ID: rs4986938) had the most augmented response of LDL-cholesterol to tamoxifen therapy when compared to other groups (p=0.03). This pattern of genotypes may identify a group of women most likely to experience cardiovascular benefits from tamoxifen. Clinical Pharmacology & Therapeutics (2004) 75, P2–P2; doi: 10.1016/j.clpt.2003.11.005" @default.
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- W2139083307 date "2004-02-01" @default.
- W2139083307 modified "2023-09-26" @default.
- W2139083307 title "ER-alpha and ER-beta genotypes predict tamoxifen effects on serum lipids in breast cancer patients" @default.
- W2139083307 doi "https://doi.org/10.1016/j.clpt.2003.11.005" @default.
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