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• W2139086387 abstract "Centrosomes orchestrate microtubule nucleation and spindle assembly during cell division [1Doxsey S. The centrosome — a tiny organelle with big potential.Nat Genet. 1998; 20: 104-106Crossref PubMed Scopus (90) Google Scholar, 2Urbani L. Stearns T. The centrosome.Curr Biol. 1999; 9: R315-317Abstract Full Text Full Text PDF PubMed Scopus (54) Google Scholar] and have long been recognized as major anchoring sites for cAMP-dependent protein kinase (PKA) [3De Camilli P. Moretti M. Donini S.D. Walter U. Lohmann S.M. Heterogenous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex.J Cell Biol. 1986; 103: 189-203Crossref PubMed Scopus (143) Google Scholar, 4Nigg E.A. Schafer G. Hilz H. Eppenberger H.M. Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes.Cell. 1985; 41: 1039-1051Abstract Full Text PDF PubMed Scopus (157) Google Scholar]. Subcellular compartmentalization of PKA is achieved through the association of the PKA holoenzyme with A-kinase anchoring proteins (AKAPs) [5Pawson T. Scott J.D. Signaling through scaffold, anchoring, and adaptor proteins.Science. 1997; 278: 2075-2080Crossref PubMed Scopus (1847) Google Scholar, 6Colledge M. Scott J.D. AKAPs: from structure to function.Trends Cell Biol. 1999; 9: 216-221Abstract Full Text Full Text PDF PubMed Scopus (523) Google Scholar]. AKAPs have been shown to contain a conserved helical motif, responsible for binding to the type II regulatory subunit (RII) of PKA, and a specific targeting motif unique to each anchoring protein that directs the kinase to specific intracellular locations. Here, we show that pericentrin, an integral component of the pericentriolar matrix of the centrosome that has been shown to regulate centrosome assembly and organization, directly interacts with PKA through a newly identified binding domain. We demonstrate that both RII and the catalytic subunit of PKA coimmunoprecipitate with pericentrin isolated from HEK-293 cell extracts and that PKA catalytic activity is enriched in pericentrin immunoprecipitates. The interaction of pericentrin with RII is mediated through a binding domain of 100 amino acids which does not exhibit the structural characteristics of similar regions on conventional AKAPs. Collectively, these results provide strong evidence that pericentrin is an AKAP in vivo." @default.
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• W2139086387 date "2000-04-01" @default.
• W2139086387 modified "2023-09-30" @default.
• W2139086387 title "Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain" @default.
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• W2139086387 doi "https://doi.org/10.1016/s0960-9822(00)00422-x" @default.
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