FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139128291> ?p ?o ?g. }

• W2139128291 abstract "T lymphocytes respond to a broad array of pathogens with the combinatorial diversity of the T cell receptor (TCR). This adaptive response is possible because of the unique structure of the TCR, which is composed of two chains, either αβ or γδ, that undergo genetic rearrangement in the thymus. αβ and γδ T cells are functionally distinct within the host but are derived from a common multipotent precursor. The canonical model for T cell lineage commitment assumes that the γ, δ, and β chains rearrange before αβ or γδ T cell commitment. To test the standard model in humans, we used high-throughput sequencing to catalog millions of TCRγ and TCRβ chains from peripheral blood αβ and γδ T cells from three unrelated individuals. Almost all sampled αβ and γδ T cells had rearranged TCRγ sequences. Although sampled αβ T cells had a diverse repertoire of rearranged TCRβ chains, less than 4% of γδ T cells in peripheral blood had a rearranged TCRβ chain. Our data suggest that TCRγ rearranges in all T lymphocytes, consistent with TCRγ rearranging before T cell lineage commitment. However, rearrangement of the TCRβ locus appears to be restricted after T cell precursors commit to the αβ T cell lineage. Indeed, in T cell leukemias and lymphomas, TCRγ is almost always rearranged and TCRβ is only rearranged in a subset of cancers. Because high-throughput sequencing of TCRs is translated into the clinic for monitoring minimal residual for leukemia/lymphoma, our data suggest the sequencing target should be TCRγ." @default.
• W2139128291 created "2016-06-24" @default.
• W2139128291 creator A5014073389 @default.
• W2139128291 creator A5015970952 @default.
• W2139128291 creator A5026350130 @default.
• W2139128291 creator A5057518319 @default.
• W2139128291 creator A5083671777 @default.
• W2139128291 creator A5086695546 @default.
• W2139128291 creator A5086740436 @default.
• W2139128291 date "2011-07-06" @default.
• W2139128291 modified "2023-10-06" @default.
• W2139128291 title "Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After αβ and γδ T Cell Commitment" @default.
• W2139128291 cites W1544076059 @default.
• W2139128291 cites W1557090560 @default.
• W2139128291 cites W1563654247 @default.
• W2139128291 cites W1587765371 @default.
• W2139128291 cites W1590546364 @default.
• W2139128291 cites W1652051777 @default.
• W2139128291 cites W1895004653 @default.
• W2139128291 cites W1965283063 @default.
• W2139128291 cites W1968983743 @default.
• W2139128291 cites W1979517153 @default.
• W2139128291 cites W1984764164 @default.
• W2139128291 cites W1989223689 @default.
• W2139128291 cites W1997063741 @default.
• W2139128291 cites W2013889679 @default.
• W2139128291 cites W2018540827 @default.
• W2139128291 cites W2022050925 @default.
• W2139128291 cites W2023441364 @default.
• W2139128291 cites W2040901489 @default.
• W2139128291 cites W2043071551 @default.
• W2139128291 cites W2043402384 @default.
• W2139128291 cites W2043473451 @default.
• W2139128291 cites W2049595543 @default.
• W2139128291 cites W2055181136 @default.
• W2139128291 cites W2056086538 @default.
• W2139128291 cites W2057078344 @default.
• W2139128291 cites W2059113040 @default.
• W2139128291 cites W2072718601 @default.
• W2139128291 cites W2077959661 @default.
• W2139128291 cites W2078191138 @default.
• W2139128291 cites W2079254194 @default.
• W2139128291 cites W2079588771 @default.
• W2139128291 cites W2081648804 @default.
• W2139128291 cites W2111261715 @default.
• W2139128291 cites W2113617961 @default.
• W2139128291 cites W2114951959 @default.
• W2139128291 cites W2119429726 @default.
• W2139128291 cites W2136145671 @default.
• W2139128291 cites W2138147017 @default.
• W2139128291 cites W2150876158 @default.
• W2139128291 cites W2158686006 @default.
• W2139128291 cites W2410273690 @default.
• W2139128291 cites W4313341461 @default.
• W2139128291 cites W4313342461 @default.
• W2139128291 doi "https://doi.org/10.1126/scitranslmed.3002536" @default.
• W2139128291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4179204" @default.
• W2139128291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21734177" @default.
• W2139128291 hasPublicationYear "2011" @default.
• W2139128291 type Work @default.
• W2139128291 sameAs 2139128291 @default.
• W2139128291 citedByCount "120" @default.
• W2139128291 countsByYear W21391282912012 @default.
• W2139128291 countsByYear W21391282912013 @default.
• W2139128291 countsByYear W21391282912014 @default.
• W2139128291 countsByYear W21391282912015 @default.
• W2139128291 countsByYear W21391282912016 @default.
• W2139128291 countsByYear W21391282912017 @default.
• W2139128291 countsByYear W21391282912018 @default.
• W2139128291 countsByYear W21391282912019 @default.
• W2139128291 countsByYear W21391282912020 @default.
• W2139128291 countsByYear W21391282912021 @default.
• W2139128291 countsByYear W21391282912022 @default.
• W2139128291 countsByYear W21391282912023 @default.
• W2139128291 crossrefType "journal-article" @default.
• W2139128291 hasAuthorship W2139128291A5014073389 @default.
• W2139128291 hasAuthorship W2139128291A5015970952 @default.
• W2139128291 hasAuthorship W2139128291A5026350130 @default.
• W2139128291 hasAuthorship W2139128291A5057518319 @default.
• W2139128291 hasAuthorship W2139128291A5083671777 @default.
• W2139128291 hasAuthorship W2139128291A5086695546 @default.
• W2139128291 hasAuthorship W2139128291A5086740436 @default.
• W2139128291 hasBestOaLocation W21391282912 @default.
• W2139128291 hasConcept C104317684 @default.
• W2139128291 hasConcept C19317047 @default.
• W2139128291 hasConcept C2776090121 @default.
• W2139128291 hasConcept C2776817793 @default.
• W2139128291 hasConcept C2778794311 @default.
• W2139128291 hasConcept C2992511266 @default.
• W2139128291 hasConcept C54355233 @default.
• W2139128291 hasConcept C86803240 @default.
• W2139128291 hasConcept C8891405 @default.
• W2139128291 hasConceptScore W2139128291C104317684 @default.
• W2139128291 hasConceptScore W2139128291C19317047 @default.
• W2139128291 hasConceptScore W2139128291C2776090121 @default.
• W2139128291 hasConceptScore W2139128291C2776817793 @default.
• W2139128291 hasConceptScore W2139128291C2778794311 @default.
• W2139128291 hasConceptScore W2139128291C2992511266 @default.
• W2139128291 hasConceptScore W2139128291C54355233 @default.
• W2139128291 hasConceptScore W2139128291C86803240 @default.

• next