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• W2139131906 endingPage "2647" @default.
• W2139131906 startingPage "2637" @default.
• W2139131906 abstract "The Extra sex combs (ESC) protein is a Polycomb group (PcG) repressor that is a key noncatalytic subunit in the ESC-Enhancer of zeste [E(Z)] histone methyltransferase complex. Survival of esc homozygotes to adulthood based solely on maternal product and peak ESC expression during embryonic stages indicate that ESC is most critical during early development. In contrast, two other PcG repressors in the same complex, E(Z) and Suppressor of zeste-12 [SU(Z)12], are required throughout development for viability and Hox gene repression. Here we describe a novel fly PcG repressor, called ESC-Like (ESCL), whose biochemical, molecular, and genetic properties can explain the long-standing paradox of ESC dispensability during postembryonic times. Developmental Western blots show that ESCL, which is 60% identical to ESC, is expressed with peak abundance during postembryonic stages. Recombinant complexes containing ESCL in place of ESC can methylate histone H3 with activity levels, and lysine specificity for K27, similar to that of the ESC-containing complex. Coimmunoprecipitations show that ESCL associates with E(Z) in postembryonic cells and chromatin immunoprecipitations show that ESCL tracks closely with E(Z) on Ubx regulatory DNA in wing discs. Furthermore, reduced escl+ dosage enhances esc loss-of-function phenotypes and double RNA interference knockdown of ESC/ESCL in wing disc-derived cells causes Ubx derepression. These results suggest that ESCL and ESC have similar functions in E(Z) methyltransferase complexes but are differentially deployed as development proceeds." @default.
• W2139131906 created "2016-06-24" @default.
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• W2139131906 date "2006-04-01" @default.
• W2139131906 modified "2023-10-16" @default.
• W2139131906 title "Alternative ESC and ESC-Like Subunits of a Polycomb Group Histone Methyltransferase Complex Are Differentially Deployed during <i>Drosophila</i> Development" @default.
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• W2139131906 doi "https://doi.org/10.1128/mcb.26.7.2637-2647.2006" @default.
• W2139131906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1430321" @default.
• W2139131906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16537908" @default.
• W2139131906 hasPublicationYear "2006" @default.
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