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• W2139136977 startingPage "R1586" @default.
• W2139136977 abstract "Integrins are transmembrane heterodimeric proteins that link extracellular matrix (ECM) to cytoskeleton and have been shown to function as mechanotransducers in nonmuscle cells. Synthetic integrin-binding peptide triggers Ca 2+ mobilization and contraction in vascular smooth muscle cells (VSMCs) of rat afferent arteriole, indicating that interactions between the ECM and integrins modulate vascular tone. To examine whether integrins transduce extracellular mechanical stress into intracellular Ca 2+ signaling events in VSMCs, unidirectional mechanical force was applied to freshly isolated renal VSMCs through paramagnetic beads coated with fibronectin (natural ligand of α 5 β 1 -integrin in VSMCs). Pulling of fibronectin-coated beads with an electromagnet triggered Ca 2+ sparks, followed by global Ca 2+ mobilization. Paramagnetic beads coated with low-density lipoprotein, whose receptors are not linked to cytoskeleton, were minimally effective in triggering Ca 2+ sparks and global Ca 2+ mobilization. Preincubation with ryanodine, cytochalasin-D, or colchicine substantially reduced the occurrence of Ca 2+ sparks triggered by fibronectin-coated beads. Binding of VSMCs with antibodies specific to the extracellular domains of α 5- and β 1 -integrins triggered Ca 2+ sparks simulating the effects of fibronectin-coated beads. Preincubation of microperfused afferent arterioles with ryanodine or integrin-specific binding peptide inhibited pressure-induced myogenic constriction. In conclusion, integrins transduce mechanical force into intracellular Ca 2+ signaling events in renal VSMCs. Integrin-mediated mechanotransduction is probably involved in myogenic response of afferent arterioles." @default.
• W2139136977 created "2016-06-24" @default.
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• W2139136977 date "2007-10-01" @default.
• W2139136977 modified "2023-10-12" @default.
• W2139136977 title "Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks" @default.
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• W2139136977 doi "https://doi.org/10.1152/ajpregu.00025.2007" @default.
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