FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139138798> ?p ?o ?g. }

• W2139138798 endingPage "1693" @default.
• W2139138798 startingPage "1683" @default.
• W2139138798 abstract "Graft versus host disease (GVHD) prevents potentially curative allogeneic stem cell transplantation from being offered to cancer patients who lack a suitably matched donor. New methods to prevent GVHD are required to allow successful transplants across major histocompatibility complex barriers.A model of GVHD in C.B-17 SCID mice was developed to allow the study of allo-activated donor T cells without confounding effects of host lymphocytes. The abilities of cyclosporin-A, anticytokine antibodies, and oxidative stress to prevent GVHD in this model was studied.T cells from major histocompatibility-mismatched donor mice caused severe GVHD in sublethally irradiated SCID hosts that could be ameliorated by coadministration of donor bone marrow but not by cyclosporine-A or anticytokine antibodies. In contrast, three-log more T cells could be injected without clinical consequences if they had been pretreated with a combination of heat, ultraviolet light, and oxygenation. The effect was not the trivial result of donor T cell destruction because T cell reconstitution, although delayed, recovered to normal levels within 2 weeks. Protection from GVHD required oxygenation and was associated with normalization of the CD4/CD8 donor T cell ratio, recovery of host hematopoiesis, and decreased inflammatory cytokine production.Pretreatment of donor T cells with a combination of physicochemical stressors effectively prevents GVHD caused by major major histocompatibility disparities and may facilitate the safe transplantation of patients without HLA-identical donors." @default.
• W2139138798 created "2016-06-24" @default.
• W2139138798 creator A5058083423 @default.
• W2139138798 creator A5075162277 @default.
• W2139138798 creator A5091653815 @default.
• W2139138798 date "2000-12-01" @default.
• W2139138798 modified "2023-09-27" @default.
• W2139138798 title "CHARACTERIZATION OF GRAFT-VERSUS-HOST DISEASE IN SCID MICE AND PREVENTION BY PHYSICOCHEMICAL STRESSORS" @default.
• W2139138798 cites W102229543 @default.
• W2139138798 cites W109430254 @default.
• W2139138798 cites W114565271 @default.
• W2139138798 cites W1491641145 @default.
• W2139138798 cites W1526571057 @default.
• W2139138798 cites W1786911182 @default.
• W2139138798 cites W1795844187 @default.
• W2139138798 cites W1895680870 @default.
• W2139138798 cites W189786127 @default.
• W2139138798 cites W1951884638 @default.
• W2139138798 cites W1965832247 @default.
• W2139138798 cites W1982538054 @default.
• W2139138798 cites W1982647833 @default.
• W2139138798 cites W1984923085 @default.
• W2139138798 cites W1986356667 @default.
• W2139138798 cites W1988389319 @default.
• W2139138798 cites W1994720817 @default.
• W2139138798 cites W2020661968 @default.
• W2139138798 cites W2028095981 @default.
• W2139138798 cites W2030570585 @default.
• W2139138798 cites W2036276239 @default.
• W2139138798 cites W2057792409 @default.
• W2139138798 cites W2058939705 @default.
• W2139138798 cites W2068487122 @default.
• W2139138798 cites W2070379407 @default.
• W2139138798 cites W2083331853 @default.
• W2139138798 cites W2084093106 @default.
• W2139138798 cites W2087313496 @default.
• W2139138798 cites W2092192751 @default.
• W2139138798 cites W2095904580 @default.
• W2139138798 cites W2102491828 @default.
• W2139138798 cites W2122118499 @default.
• W2139138798 cites W2136353300 @default.
• W2139138798 cites W2139099642 @default.
• W2139138798 cites W2143685541 @default.
• W2139138798 cites W2145771474 @default.
• W2139138798 cites W2153191296 @default.
• W2139138798 cites W2165835604 @default.
• W2139138798 cites W2173547083 @default.
• W2139138798 cites W2287087682 @default.
• W2139138798 cites W2317548431 @default.
• W2139138798 cites W2411848158 @default.
• W2139138798 cites W2434525932 @default.
• W2139138798 cites W261184483 @default.
• W2139138798 cites W40822599 @default.
• W2139138798 doi "https://doi.org/10.1097/00007890-200012270-00004" @default.
• W2139138798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11152097" @default.
• W2139138798 hasPublicationYear "2000" @default.
• W2139138798 type Work @default.
• W2139138798 sameAs 2139138798 @default.
• W2139138798 citedByCount "8" @default.
• W2139138798 countsByYear W21391387982018 @default.
• W2139138798 crossrefType "journal-article" @default.
• W2139138798 hasAuthorship W2139138798A5058083423 @default.
• W2139138798 hasAuthorship W2139138798A5075162277 @default.
• W2139138798 hasAuthorship W2139138798A5091653815 @default.
• W2139138798 hasConcept C126322002 @default.
• W2139138798 hasConcept C147483822 @default.
• W2139138798 hasConcept C154317977 @default.
• W2139138798 hasConcept C159654299 @default.
• W2139138798 hasConcept C167672396 @default.
• W2139138798 hasConcept C188280979 @default.
• W2139138798 hasConcept C202751555 @default.
• W2139138798 hasConcept C202965653 @default.
• W2139138798 hasConcept C203014093 @default.
• W2139138798 hasConcept C207936829 @default.
• W2139138798 hasConcept C2776090121 @default.
• W2139138798 hasConcept C2777408962 @default.
• W2139138798 hasConcept C2779972918 @default.
• W2139138798 hasConcept C28328180 @default.
• W2139138798 hasConcept C2911091166 @default.
• W2139138798 hasConcept C48556533 @default.
• W2139138798 hasConcept C54355233 @default.
• W2139138798 hasConcept C55493867 @default.
• W2139138798 hasConcept C71924100 @default.
• W2139138798 hasConcept C86803240 @default.
• W2139138798 hasConcept C8891405 @default.
• W2139138798 hasConceptScore W2139138798C126322002 @default.
• W2139138798 hasConceptScore W2139138798C147483822 @default.
• W2139138798 hasConceptScore W2139138798C154317977 @default.
• W2139138798 hasConceptScore W2139138798C159654299 @default.
• W2139138798 hasConceptScore W2139138798C167672396 @default.
• W2139138798 hasConceptScore W2139138798C188280979 @default.
• W2139138798 hasConceptScore W2139138798C202751555 @default.
• W2139138798 hasConceptScore W2139138798C202965653 @default.
• W2139138798 hasConceptScore W2139138798C203014093 @default.
• W2139138798 hasConceptScore W2139138798C207936829 @default.
• W2139138798 hasConceptScore W2139138798C2776090121 @default.
• W2139138798 hasConceptScore W2139138798C2777408962 @default.
• W2139138798 hasConceptScore W2139138798C2779972918 @default.

• next