Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139142867> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2139142867 endingPage "S128" @default.
- W2139142867 startingPage "S126" @default.
- W2139142867 abstract "Synchrotron light offers new radiation treatment strategies including binary therapies, such as photoactivation therapy (PAT) where the photoelectric interaction in a high-Z material leads to a localized source of high LET particles, e.g. Auger electrons. Microdosimetry is used to assess the efficacy of mixed field and binary radiation treatments and describes the clustering of radiation damage on the micron scale due to particles of differing type, energy and origin. The modeling of microdosimetric distributions in varying treatment scenarios, however, relies on accurate electron physics at sub-micron dimensions, challenging the capabilities of current Monte Carlo codes. The intercomparison of measured and modeled microdosimetric spectra from monochromatic X-rays therefore provides a test of electron transport algorithms and fundamental cross-section data. Microdosimetric spectra are compared for Monte Carlo calculations based on atomic and molecular models of the solid and gaseous components of the detector and to spectra calculated in a water medium for spherical volumes of 100 and 1000 nm diameter. Radiobiology experiments show substantial variation in the photon radiobiological effect (RBE) for end-points, such as cell death and transformation. The microdosimetric model indicates that, with careful tuning of the synchrotron energy, a radiobiological advantage can be achieved in photoactivation therapies in addition to dose enhancement." @default.
- W2139142867 created "2016-06-24" @default.
- W2139142867 creator A5057007995 @default.
- W2139142867 date "2008-12-01" @default.
- W2139142867 modified "2023-10-16" @default.
- W2139142867 title "Microdosimetry in X-ray synchrotron based binary radiation therapy" @default.
- W2139142867 cites W1972176301 @default.
- W2139142867 cites W1976622734 @default.
- W2139142867 cites W2012638191 @default.
- W2139142867 cites W2035882306 @default.
- W2139142867 cites W2042972298 @default.
- W2139142867 cites W2064026401 @default.
- W2139142867 cites W2068610464 @default.
- W2139142867 cites W2074652836 @default.
- W2139142867 cites W2075508978 @default.
- W2139142867 cites W2076196129 @default.
- W2139142867 cites W2083043432 @default.
- W2139142867 cites W2110741904 @default.
- W2139142867 cites W2141308200 @default.
- W2139142867 cites W2323415565 @default.
- W2139142867 doi "https://doi.org/10.1016/j.ejrad.2008.04.056" @default.
- W2139142867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18599233" @default.
- W2139142867 hasPublicationYear "2008" @default.
- W2139142867 type Work @default.
- W2139142867 sameAs 2139142867 @default.
- W2139142867 citedByCount "6" @default.
- W2139142867 countsByYear W21391428672012 @default.
- W2139142867 countsByYear W21391428672013 @default.
- W2139142867 countsByYear W21391428672018 @default.
- W2139142867 crossrefType "journal-article" @default.
- W2139142867 hasAuthorship W2139142867A5057007995 @default.
- W2139142867 hasConcept C105795698 @default.
- W2139142867 hasConcept C111337013 @default.
- W2139142867 hasConcept C120665830 @default.
- W2139142867 hasConcept C121332964 @default.
- W2139142867 hasConcept C125118446 @default.
- W2139142867 hasConcept C147120987 @default.
- W2139142867 hasConcept C159317903 @default.
- W2139142867 hasConcept C16332341 @default.
- W2139142867 hasConcept C185544564 @default.
- W2139142867 hasConcept C19499675 @default.
- W2139142867 hasConcept C19527891 @default.
- W2139142867 hasConcept C21368211 @default.
- W2139142867 hasConcept C2989005 @default.
- W2139142867 hasConcept C2993559085 @default.
- W2139142867 hasConcept C30475298 @default.
- W2139142867 hasConcept C33923547 @default.
- W2139142867 hasConcept C71924100 @default.
- W2139142867 hasConcept C75088862 @default.
- W2139142867 hasConceptScore W2139142867C105795698 @default.
- W2139142867 hasConceptScore W2139142867C111337013 @default.
- W2139142867 hasConceptScore W2139142867C120665830 @default.
- W2139142867 hasConceptScore W2139142867C121332964 @default.
- W2139142867 hasConceptScore W2139142867C125118446 @default.
- W2139142867 hasConceptScore W2139142867C147120987 @default.
- W2139142867 hasConceptScore W2139142867C159317903 @default.
- W2139142867 hasConceptScore W2139142867C16332341 @default.
- W2139142867 hasConceptScore W2139142867C185544564 @default.
- W2139142867 hasConceptScore W2139142867C19499675 @default.
- W2139142867 hasConceptScore W2139142867C19527891 @default.
- W2139142867 hasConceptScore W2139142867C21368211 @default.
- W2139142867 hasConceptScore W2139142867C2989005 @default.
- W2139142867 hasConceptScore W2139142867C2993559085 @default.
- W2139142867 hasConceptScore W2139142867C30475298 @default.
- W2139142867 hasConceptScore W2139142867C33923547 @default.
- W2139142867 hasConceptScore W2139142867C71924100 @default.
- W2139142867 hasConceptScore W2139142867C75088862 @default.
- W2139142867 hasIssue "3" @default.
- W2139142867 hasLocation W21391428671 @default.
- W2139142867 hasLocation W21391428672 @default.
- W2139142867 hasOpenAccess W2139142867 @default.
- W2139142867 hasPrimaryLocation W21391428671 @default.
- W2139142867 hasRelatedWork W1511566139 @default.
- W2139142867 hasRelatedWork W1518584473 @default.
- W2139142867 hasRelatedWork W1670732023 @default.
- W2139142867 hasRelatedWork W2017884723 @default.
- W2139142867 hasRelatedWork W2088257409 @default.
- W2139142867 hasRelatedWork W2091796379 @default.
- W2139142867 hasRelatedWork W2092020115 @default.
- W2139142867 hasRelatedWork W2889103515 @default.
- W2139142867 hasRelatedWork W3102196204 @default.
- W2139142867 hasRelatedWork W3184197832 @default.
- W2139142867 hasVolume "68" @default.
- W2139142867 isParatext "false" @default.
- W2139142867 isRetracted "false" @default.
- W2139142867 magId "2139142867" @default.
- W2139142867 workType "article" @default.